Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RYR3 (Q15413) - Overview - Molecular Target Synopsis


RYR3, Ryanodine receptor 3
UniProt Q15413

Also Known as RYR3_HUMAN, RYR3, HBRR

Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling. Homotetramer. Heterotetramer with RYR2. Interacts with CALM (By similarity). Interacts with FKBP1A. Interacts with SELENON.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform


RYR3 is targeted by Approved Drug Dantrolene. (see details)

Sub-cellular localization

UniProt: RYR3 is active in the following subcellular-locations: membrane, microsome membrane, sarcoplasmic reticulum, sarcoplasmic reticulum membrane.
GO terms: RYR3 is active in the following subcellular-locations: calcium channel complex, cytoplasmic vesicle membrane, integral component of membrane, perinuclear region of cytoplasm, plasma membrane, sarcolemma, sarcoplasmic reticulum, sarcoplasmic reticulum membrane, smooth endoplasmic reticulum, Z disc.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RYR3 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SF_539, U251, NCI_H460

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SJCRH30, SET-2, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures

For RYR3 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

RYR3 has been screened with compounds ( bioactivities). (see details)