Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RYR3 (Q15413) - Overview - Molecular Target Synopsis

Protein


RYR3, Ryanodine receptor 3
UniProt Q15413

Also Known as RYR3_HUMAN, RYR3, HBRR

Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling. Homotetramer. Heterotetramer with RYR2. Interacts with CALM (By similarity). Interacts with FKBP1A. Interacts with SELENON.

4ERV
CRYSTAL STRUCTURE OF HUMAN RYANODINE RECEPTOR 3 (2597-2800)
RCSB/PDB
Inspect Structure
See all 3D Structures for RYR3

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
4870ENSG00000198838ENST00000389232ENSP00000373884Q15413-1
4865ENSG00000198838ENST00000415757ENSP00000399610Q15413-2
3859Q15413-3

Drugs


RYR3 is targeted by Approved Drug Dantrolene. (see details)
Dantrolene

Sub-cellular localization


UniProt: RYR3 is active in the following subcellular-locations: membrane, microsome membrane, sarcoplasmic reticulum, sarcoplasmic reticulum membrane.
GO terms: RYR3 is active in the following subcellular-locations: calcium channel complex, cytoplasmic vesicle membrane, integral component of membrane, perinuclear region of cytoplasm, plasma membrane, sarcolemma, sarcoplasmic reticulum, sarcoplasmic reticulum membrane, smooth endoplasmic reticulum, Z disc.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RYR3 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SF_539, U251, NCI_H460

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SJCRH30, SET-2, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For RYR3 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RYR3 has been screened with compounds ( bioactivities). (see details)