RYR3 (Q15413) - Overview - Molecular Target Synopsis
RYR3, Ryanodine receptor 3
Also Known as RYR3_HUMAN, RYR3, HBRR
Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling. Homotetramer. Heterotetramer with RYR2. Interacts with CALM (By similarity). Interacts with FKBP1A. Interacts with SELENON.
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UniProt: RYR3 is active in the following subcellular-locations: membrane, microsome membrane, sarcoplasmic reticulum, sarcoplasmic reticulum membrane.
GO terms: RYR3 is active in the following subcellular-locations: calcium channel complex, cytoplasmic vesicle membrane, integral component of membrane, perinuclear region of cytoplasm, plasma membrane, sarcolemma, sarcoplasmic reticulum, sarcoplasmic reticulum membrane, smooth endoplasmic reticulum, Z disc.