Molecular Target Synopsis
Overview
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RHEB (Q15382) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed18
Chains with at least one site assessed as druggable using the strict criteria8
Chains with at least one site assessed as druggable using the relaxed criteria16


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5YXH_C GTP-binding protein Rheb Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 63.8 31.8 Yes No
2 bound 1.94 81.3 15.5 Yes Yes
3 empty 2.27 64.8 10.1 No No
4 empty 2.22 72.2 7.7 No No
5 empty 2.45 69.8 9.1 No No
6 empty 1.88 68.4 8.8 No No
7 empty 3.05 58.6 10.5 No No
8 empty 3.02 60 9.6 No No
9 empty 2.43 68.8 12.5 No No
10 empty 2.39 61 10.7 No No
3SEA_B GTP-binding protein Rheb Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 65.6 28.8 Yes No
2 bound 1.99 72.2 30.1 No No
3 bound 2.31 67.5 12 No No
4 empty 2.4 62.8 20.2 No No
5 empty 2.52 59.5 14.3 No No
6 empty 2.59 52.1 11.7 No No
7 empty 1.73 65.6 10.2 No No
8 empty 2.92 51.6 10 No No
9 empty 2.32 57.7 11.2 No No
10 empty 1.82 64.4 5.3 No No
5YXH_A GTP-binding protein Rheb Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.25 65.1 28.6 Yes No
2 bound 2.05 79 21.4 Yes Yes
3 empty 1.93 63.3 16.6 No No
4 empty 2.27 72.7 10.3 No No
5 empty 2.62 56.4 8.5 No No
6 empty 2.1 67.5 8.3 No No
7 empty 2.15 59.1 11.7 No No
8 empty 2.6 70.4 6.8 No No
9 empty 1.81 73.6 7.1 No No
10 empty 2.26 76.1 8.2 No No
6BSX_A GTP-binding protein Rheb Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 71.7 25.4 Yes No
2 empty 2.27 72.7 15.4 No No
3 bound 1.97 68.4 18.2 No No
4 empty 1.79 71.3 12.1 No No
5 empty 2.09 64.8 17.6 No No
6 empty 2.31 74.8 8.5 No No
7 empty 2.87 62.5 9.8 No No
8 empty 2.67 71.2 11.9 No No
9 empty 2.25 60.9 12.1 No No
10 empty 2.45 73.5 6.8 No No
1XTQ_A GTP-binding protein Rheb Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.23 72.9 25.4 Yes No
2 empty 2.46 68.6 16.4 No No
3 empty 2.47 66.7 19.8 No No
4 empty 2.54 70.8 12.2 No No
5 empty 2.34 65.2 9.1 No No
6 empty 2.58 59.5 11.5 No No
7 empty 2.57 59.1 14.3 No No
8 empty 2.95 61 10.2 No No
9 empty 2.66 65.9 7.1 No No
10 empty 1.89 69.7 6.9 No No
6BT0_A GTP-binding protein Rheb Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.15 72.6 25.3 Yes No
2 empty 2.42 70.2 21 No No
3 empty 1.75 71.2 14.1 No No
4 empty 2.07 65.5 14.3 No No
5 empty 2.08 54.4 14.8 No No
6 empty 1.99 63 14.4 No No
7 empty 2.26 66.7 7.5 No No
8 empty 3.03 52.7 8.5 No No
9 empty 2.7 64.5 10 No No
10 empty 2.49 61.1 7.9 No No
3SEA_A GTP-binding protein Rheb Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.51 69.9 26.9 Yes No
2 empty 2.12 69.1 23.7 No No
3 bound 2.22 76.8 21.6 No No
4 empty 2.63 61.6 11.4 No No
5 empty 2.71 69.5 8.3 No No
6 empty 2.39 58.3 11 No No
7 empty 2.46 65.4 11.3 No No
8 empty 2.04 65.6 7.8 No No
9 empty 2.42 58.2 8.5 No No
10 empty 2.6 77.4 7.2 No No
6BSX_B GTP-binding protein Rheb No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.33 70.7 21.2 No No
2 bound 2.04 78.5 15.3 No No
3 bound 1.83 67.5 19.9 No No
4 empty 1.87 69.1 12.2 No No
5 empty 2.35 61.9 11.7 No No
6 empty 2.12 65.2 17.9 No No
7 empty 2.29 75.7 9.3 No No
8 empty 2.76 65.6 8.9 No No
9 empty 2.6 65.4 10.6 No No
10 empty 2.17 61.6 9.5 No No
5YXH_D GTP-binding protein Rheb Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.44 71.1 24.4 Yes No
2 empty 2.18 67.8 26.3 No No
3 bound 2.12 76.7 20.4 No No
4 empty 2.34 68.7 9.5 No No
5 empty 2.29 70.4 10.6 No No
6 empty 2.3 63.1 11.4 No No
7 empty 2.52 60.5 9.3 No No
8 empty 2.29 70.8 8.3 No No
9 empty 2.42 57.6 10.6 No No
10 empty 1.89 69.2 7.6 No No
1XTS_A GTP-binding protein Rheb Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.37 71.6 24.9 Yes Yes
2 empty 2.41 68.2 21.7 No No
3 empty 2.15 66.2 18.9 No No
4 empty 1.6 62.5 14.3 No No
5 empty 2.46 64.2 10.4 No No
6 empty 2.57 58.9 14.1 No No
7 empty 2.35 63.7 12.2 No No
8 empty 1.65 71.9 9.5 No No
9 empty 2.21 67.2 7.1 No No
10 empty 1.97 56.8 9.4 No No
3T5G_A GTP-binding protein Rheb Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 56 26.5 Yes No
2 bound 2.13 81.2 12.8 Yes Yes
3 empty 2.4 65 17.8 No No
4 empty 2.2 64 14.8 No No
5 empty 2.51 64.9 9.8 No No
6 empty 2.24 64.1 9.8 No No
7 empty 2.62 67 8.5 No No
8 empty 1.91 68.2 7.8 No No
9 empty 2.54 68.2 10.3 No No
10 empty 2 65.5 6.3 No No
5YXH_B GTP-binding protein Rheb No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.51 69.7 19.6 No No
2 empty 1.85 76.1 17.7 No No
3 bound 2.01 77.4 18.2 No No
4 empty 2.06 67.8 10 No No
5 empty 2.25 64.5 12.2 No No
6 empty 2.4 56.4 13.3 No No
7 empty 2.14 64.1 11.1 No No
8 empty 2.28 66.5 11.3 No No
9 empty 1.93 58.7 8.6 No No
10 empty 1.92 67 6.4 No No
1XTR_A GTP-binding protein Rheb Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.37 72.6 25.8 Yes Yes
2 empty 2.39 67.5 18.3 No No
3 empty 2.04 69.5 17.6 No No
4 bound 2.04 63.6 19.7 No No
5 empty 2.63 60.8 14.9 No No
6 empty 2.17 72.4 12.5 No No
7 empty 2.24 63.6 9.5 No No
8 empty 1.76 65.2 8.6 No No
9 empty 2.23 66.1 8 No No
10 empty 2.21 46.5 6.8 No No
6BSX_D GTP-binding protein Rheb Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 69 27.7 Yes Yes
2 bound 2.19 70.9 28.3 No No
3 empty 2.83 65 10.3 No No
4 empty 2.4 66.8 7.7 No No
5 empty 2.25 62.3 12.3 No No
6 empty 1.94 69.2 7.1 No No
7 empty 2.61 71.1 7 No No
8 empty 2.17 57.7 8.3 No No
9 empty 2.42 57.2 9.3 No No
10 empty 2.69 68.8 6.2 No No
6BSX_C GTP-binding protein Rheb Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.47 65.7 29.8 Yes No
2 bound 2.2 68.7 19.8 No No
3 bound 2.05 80.8 12.8 No No
4 empty 2.65 66.5 11.5 No No
5 empty 2.95 69 7 No No
6 empty 2.3 64.7 9.8 No No
7 empty 1.95 68.2 8.4 No No
8 empty 2.13 53.4 9.2 No No
9 empty 2.59 74 7.8 No No
10 empty 2.66 67.1 8.8 No No
6BT0_D GTP-binding protein Rheb Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.42 68.5 31.6 Yes No
2 bound 2.1 79.9 20.9 Yes Yes
3 empty 1.76 73.7 16.8 No No
4 empty 2.12 74.6 22.7 No No
5 empty 2.4 62.3 7.7 No No
6 empty 2.42 66 8.1 No No
7 empty 2.17 63.1 10.9 No No
8 empty 2.46 59.9 8.2 No No
9 empty 2.22 68.7 8.5 No No
10 empty 2.51 76.2 5.4 No No
6BT0_B GTP-binding protein Rheb Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.45 68.9 30.2 Yes No
2 bound 2.03 80.9 13.7 Yes Yes
3 bound 1.87 72 14.5 No No
4 empty 2.33 64 24.8 No No
5 empty 2.14 66.9 10.8 No No
6 empty 2.47 64.5 17.3 No No
7 empty 2.03 52.8 13.3 No No
8 empty 2.16 69.1 8.9 No No
9 empty 2.31 64.8 11.6 No No
10 empty 2.21 62.7 9.1 No No
6BT0_C GTP-binding protein Rheb Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.57 72.7 18.6 Yes No
2 empty 2.2 70 22.6 No No
3 bound 2.15 79.9 16.4 No No
4 empty 2.03 68.5 15.3 No No
5 empty 2.24 64 17.1 No No
6 empty 2.49 67.6 12.4 No No
7 empty 2.28 59.9 17.8 No No
8 empty 2.81 63.3 9.9 No No
9 empty 2.27 53.6 7.1 No No
10 empty 2.55 65.3 7.6 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed4
Domains assessed as druggable using the strict criteria1
Domains assessed as druggable using the relaxed criteria4

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1XTQ_A (122297) GTP-binding protein Rheb P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 2Å Yes No
1XTR_A (122298) GTP-binding protein Rheb P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 2.65Å Yes No
1XTS_A (122299) GTP-binding protein Rheb P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 2.8Å Yes No
3T5G_A (4164291) GTP-binding protein Rheb P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 1.7Å Yes Yes
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


RHEB is involved in 22 interactions in the network.


Druggability
Overall Druggability Percentile: 87.58
Druggability for Cancer Therapeutics: 85.05
Druggability for Other Therapeutics: 94.58
Cancer-Associated
Cancer-associated percentile : 83.63
Network Articulation Point
Is RHEB critical for communication in the network?


Detailed Graph Legend:Help