Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RHEB (Q15382) - Overview - Molecular Target Synopsis

Protein


RHEB, GTP-binding protein Rheb
UniProt Q15382

Also Known as RHEB_HUMAN, RHEB, RHEB2

Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity. Binds to mTORC1 in a guanyl nucleotide-independent manner. Interacts directly with MTOR, MLST8 and RPTOR. Interacts with TSC2. Interacts (when prenylated) with PDE6D; this promotes release from membranes.

5YXH
STRUCTURE OF RHEB-GDP
RCSB/PDB
Inspect Structure
See all 3D Structures for RHEB

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RHEB is active in the following subcellular-locations: cytoplasm, cytosol, endomembrane system, endoplasmic reticulum membrane, golgi apparatus membrane.
GO terms: RHEB is active in the following subcellular-locations: cytosol, endoplasmic reticulum membrane, extracellular exosome, Golgi membrane, lysosomal membrane, membrane, postsynaptic density, spliceosomal complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RHEB has gain in 3 cell-lines, loss in 5 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HOP_92, MALME_3M, A498

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK23, HCC193, HCC1162

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, SK-N-SH

(see details)

3D Structures


For RHEB there are:
8 structures (18 chains) solved
8 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RHEB has been screened with 2 compounds (4 bioactivities). (see details)