Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

STK38 (Q15208) - Overview - Molecular Target Synopsis


STK38, Serine/threonine-protein kinase 38
Enzyme Classification
UniProt Q15208

Also Known as STK38_HUMAN, STK38, NDR1

Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2. Homodimeric S100B binds two molecules of STK38 (PubMed:14661952). Interacts with MOB1 and MOB2 (PubMed:15067004, PubMed:15197186). Interacts with MAP3K1 and MAP3K2 (via the kinase catalytic domain) (PubMed:17906693). Forms a tripartite complex with MOBKL1B and STK3/MST2 (PubMed:18362890). Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by MST1/STK4.

Inspect Structure
See all 3D Structures for STK38

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
465ENSG00000112079ENST00000229812ENSP00000229812Q15208-1, Q5R8M1-1

Sub-cellular localization

UniProt: STK38 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: STK38 is active in the following subcellular-locations: cytoplasm, cytosol, nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project STK38 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: NCI_H522, MDA_MB_231, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H522, HCC1576, WSU-FSCCL

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, NHLF, SK-N-SH

(see details)

RNA Interference

STK38 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: SCC47, OV90. (see details)

3D Structures

For STK38 there are:
2 structures (4 chains) solved
1 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

STK38 has been screened with 233 compounds (248 bioactivities), 5 compounds have bioactivities that show binding affinity of <= 500nM (7 bioactivities). (see details)