Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

EBP (Q15125) - Overview - Molecular Target Synopsis

Protein


EBP, 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
Enzyme Classification 5.3.3.5
UniProt Q15125

Also Known as EBP_HUMAN, EBP

Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: EBP is active in the following subcellular-locations: cytoplasmic vesicle, endoplasmic reticulum membrane, nucleus envelope.
GO terms: EBP is active in the following subcellular-locations: cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, integral component of plasma membrane, nuclear envelope.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project EBP has gain in 1 cell-lines, loss in 60 cell-lines and no signal in 944 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: OVCAR_4, RPMI_8226, KM12

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HuH-7, LCLC-103H, NCI-H2347

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, HeLa-S3, K562

(see details)

RNA Interference


EBP was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)


Screening and Chemistry


EBP has been screened with 145 compounds (213 bioactivities), 41 compounds have bioactivities that show binding affinity of <= 500nM (52 bioactivities). (see details)