Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RRS1 (Q15050) - Overview - Molecular Target Synopsis

Protein


RRS1, Ribosome biogenesis regulatory protein homolog
UniProt Q15050

Also Known as RRS1_HUMAN, RRS1, KIAA0112, RRR

Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
404ENSG00000179041ENST00000320270ENSP00000322396
365Q15050-1

Sub-cellular localization


UniProt: RRS1 is active in the following subcellular-locations: nucleolus, nucleus.
GO terms: RRS1 is active in the following subcellular-locations: condensed nuclear chromosome, endoplasmic reticulum, fibrillar center, nucleolus, nucleus, preribosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RRS1 has gain in 8 cell-lines, loss in 4 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: A549, OVCAR_5, BT_549

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HEY, NCI-H1299, NCI-H1975

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, SK-N-SH, IMR-90

(see details)

3D Structures


At greater than 35% identity similarity to RRS1 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis