Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB3GAP1 (Q15042) - Overview - Molecular Target Synopsis

Protein


RAB3GAP1, Rab3 GTPase-activating protein catalytic subunit
UniProt Q15042

Also Known as RB3GP_HUMAN, RAB3GAP1, KIAA0066, RAB3GAP

Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3-GAP150. The Rab3 GTPase-activating complex interacts with DMXL2 (By similarity). Interacts with LMAN1 (PubMed:22337587).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB3GAP1 is active in the following subcellular-locations: cytoplasm.
GO terms: RAB3GAP1 is active in the following subcellular-locations: cytosol, endoplasmic reticulum membrane, endoplasmic reticulum tubular network, extracellular exosome, Golgi apparatus, lipid droplet, postsynapse, protein-containing complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB3GAP1 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H226, RXF_393, ACHN

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MHH-PREB-1, Hs 746T, NCI-H82

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, AG445, BJ

(see details)