RAB3GAP1 (Q15042) - Overview - Molecular Target Synopsis
RAB3GAP1, Rab3 GTPase-activating protein catalytic subunit
Also Known as RB3GP_HUMAN, RAB3GAP1, KIAA0066, RAB3GAP
Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3-GAP150. The Rab3 GTPase-activating complex interacts with DMXL2 (By similarity). Interacts with LMAN1 (PubMed:22337587).
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
UniProt: RAB3GAP1 is active in the following subcellular-locations: cytoplasm.
GO terms: RAB3GAP1 is active in the following subcellular-locations: cytosol, endoplasmic reticulum membrane, endoplasmic reticulum tubular network, extracellular exosome, Golgi apparatus, lipid droplet, postsynapse, protein-containing complex.