Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RAB3GAP1 (Q15042) - Overview - Molecular Target Synopsis


RAB3GAP1, Rab3 GTPase-activating protein catalytic subunit
UniProt Q15042

Also Known as RB3GP_HUMAN, RAB3GAP1, KIAA0066, RAB3GAP

Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3-GAP150. The Rab3 GTPase-activating complex interacts with DMXL2 (By similarity). Interacts with LMAN1 (PubMed:22337587).

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: RAB3GAP1 is active in the following subcellular-locations: cytoplasm.
GO terms: RAB3GAP1 is active in the following subcellular-locations: cytosol, endoplasmic reticulum membrane, endoplasmic reticulum tubular network, extracellular exosome, Golgi apparatus, lipid droplet, postsynapse, protein-containing complex.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RAB3GAP1 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: NCI_H226, RXF_393, ACHN

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MHH-PREB-1, Hs 746T, NCI-H82

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, AG445, BJ

(see details)