Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RAB39A (Q14964) - Overview - Molecular Target Synopsis


RAB39A, Ras-related protein Rab-39A
UniProt Q14964

Also Known as RB39A_HUMAN, RAB39A, RAB39

Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes. Negatively regulates LPS-induced autophagosome formation in macrophages possibly by implicating PI3K (PubMed:24349490). May be involved in multiple neurite formation. Interacts with BECN1. Probably associates with the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex (PubMed:24349490). Interacts with UACA.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: RAB39A is active in the following subcellular-locations: cell membrane, cytoplasmic vesicle, lysosome, phagosome, phagosome membrane.
GO terms: RAB39A is active in the following subcellular-locations: cytosol, Golgi membrane, lysosome, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RAB39A has gain in 6 cell-lines, loss in 7 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 79, NCI-H727, SK-N-FI

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures

At greater than 50% identity similarity to RAB39A there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

RAB39A has been screened with compounds ( bioactivities). (see details)