Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC17A1 (Q14916) - Overview - Molecular Target Synopsis

Protein


SLC17A1, Sodium-dependent phosphate transport protein 1
UniProt Q14916

Also Known as NPT1_HUMAN, SLC17A1, NPT1

Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney (PubMed:27906618). Interacts with PDZK1.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC17A1 is active in the following subcellular-locations: apical cell membrane.
GO terms: SLC17A1 is active in the following subcellular-locations: apical plasma membrane, integral component of membrane, integral component of plasma membrane, lysosome, membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC17A1 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: ACHN, TK_10, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: 769-P, NCI-H28, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)


Screening and Chemistry


SLC17A1 has been screened with compounds ( bioactivities). (see details)