Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NAA30 (Q147X3) - Overview - Molecular Target Synopsis

Protein


NAA30, N-alpha-acetyltransferase 30
Enzyme Classification 2.3.1.256
UniProt Q147X3

Also Known as NAA30_HUMAN, NAA30, C14orf35, MAK3, NAT12

Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate. Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: NAA30 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: NAA30 is active in the following subcellular-locations: cytoplasm, cytosol, NatC complex, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NAA30 has gain in 4 cell-lines, loss in 1 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: LS1034, NCI-H82, OCUM-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, MCF-7, hMSC-AT

(see details)