Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GNMT (Q14749) - Overview - Molecular Target Synopsis

Protein


GNMT, Glycine N-methyltransferase
Enzyme Classification 2.1.1.20
UniProt Q14749

Also Known as GNMT_HUMAN, GNMT

Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine. Homotetramer.

2AZT
CRYSTAL STRUCTURE OF H176N MUTANT OF HUMAN GLYCINE N-METHYLTRANSFERASE
RCSB/PDB
Inspect Structure
See all 3D Structures for GNMT

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
295ENSG00000124713ENST00000372808ENSP00000361894Q14749-1

Sub-cellular localization


UniProt: GNMT is active in the following subcellular-locations: cytoplasm.
GO terms: GNMT is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GNMT has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, MOLT_4, PC_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: LNCAP, SCLC-21H, MDA-MB-361

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For GNMT there are:
2 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis