Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MFSD10 (Q14728) - Overview - Molecular Target Synopsis

Protein


MFSD10, Major facilitator superfamily domain-containing protein 10
UniProt Q14728

Also Known as MFS10_HUMAN, MFSD10, TETRAN

Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MFSD10 is active in the following subcellular-locations: membrane.
GO terms: MFSD10 is active in the following subcellular-locations: brush border membrane, cytoplasmic vesicle membrane, integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MFSD10 has gain in 0 cell-lines, loss in 5 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HL_60, HT29, CAKI_1

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: U-937, THP-1, WiDr

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, A549

(see details)