Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MBTPS1 (Q14703) - Overview - Molecular Target Synopsis

Protein


MBTPS1, Membrane-bound transcription factor site-1 protease
Enzyme Classification 3.4.21.112
UniProt Q14703

Also Known as MBTP1_HUMAN, MBTPS1, KIAA0091, S1P, SKI1

Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MBTPS1 is active in the following subcellular-locations: endoplasmic reticulum membrane, golgi apparatus membrane.
GO terms: MBTPS1 is active in the following subcellular-locations: endoplasmic reticulum lumen, endoplasmic reticulum membrane, Golgi apparatus, Golgi membrane, Golgi stack, integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MBTPS1 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, HS578T, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 695T, G111, A4/Fuk

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, BJ

(see details)


Screening and Chemistry


MBTPS1 has been screened with 35 compounds (35 bioactivities), 11 compounds have bioactivities that show binding affinity of <= 500nM (11 bioactivities). (see details)