Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ZNF268 (Q14587) - Overview - Molecular Target Synopsis

Protein


ZNF268, Zinc finger protein 268
UniProt Q14587

Also Known as ZN268_HUMAN, ZNF268

Isoform 1: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression., Isoform 2: Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex. Interacts (via the KRAB domain) with TRIM28 (via the RBCC domain); the interaction increases ZNF268 nuclear localization activity. Isoform 2 interacts with CHUK and IKBKB; the interaction is further increased in a TNF-alpha-dependent manner.

2YTF
SOLUTION STRUCTURE OF THE C2H2 TYPE ZINC FINGER (REGION 607- 639) OF HUMAN ZINC FINGER PROTEIN 268
RCSB/PDB
Inspect Structure
See all 3D Structures for ZNF268

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ZNF268 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: ZNF268 is active in the following subcellular-locations: actin cytoskeleton, cytoplasm, cytosol, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ZNF268 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_OV_3, LOXIMVI, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-134-VI, KMS-12-BM, HCC366

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HMEC, HSMM

(see details)

3D Structures


For ZNF268 there are:
23 structures (23 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ZNF268 has been screened with compounds ( bioactivities). (see details)