Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SCN5A (Q14524) - Domains And Structures - Molecular Target Synopsis

Click Here to View Molecular Target 3D Synopsis

Select a homology cutoff:
Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
Ion transport protein (5%) (view alignment) SCN2A (Q99250) - HUMAN 2KAV_A 83.96 3.0E-49 - 2009-01-06
Ion transport protein (4%) (view alignment) Scn2a (P04775) - NORWAY RAT 1BYY_A 90.57 7.0E-26 - 1999-10-29
Ion transport protein (67%), Sodium ion transport-associated (1%) (view alignment) SCN9A (Q15858), (A8EVM5) (P83476) HUMAN 6N4R_D 44.14 6.0E-11 4.2Å - 2019-01-23
Ion transport protein (67%), Sodium ion transport-associated (1%) (view alignment) SCN9A (Q15858), (A8EVM5) (P83476) HUMAN 6N4R_A 44.14 6.0E-11 4.2Å - 2019-01-23
Ion transport protein (100%), Sodium ion transport-associated (16%) (view alignment) (D0E0C2) (P49126) AMERICAN COCKROACH 6A95_A 43.93 7.0E-56 2.6Å NAG 9SR 2018-08-08
Ion transport protein (100%), Cytoplasmic domain of voltage-gated Na+ ion channel (100%), Sodium ion transport-associated (16%) (view alignment) SCN9A (Q15858) SCN1B (Q07699), SCN2B (O60939) HUMAN 6J8J_A 74.03 0 3.2Å NAG 9SR 2019-02-27
Ion transport protein (5%) (view alignment) SCN2A (Q99250) CALM3 (P0DP25), FGF13 (Q92913) HUMAN 4JPZ_B 76.4 4.0E-73 3.02Å - 2014-04-16
Ion transport protein (100%), Sodium ion transport-associated (16%) (view alignment) (D0E0C2) (P49126) AMERICAN COCKROACH 6A90_A 43.93 7.0E-56 2.8Å NAG 2018-08-08
Ion transport protein (5%) (view alignment) SCN5A (Q14524) CALM3 (P0DP25), FGF13 (Q92913) HUMAN 4DCK_A 100 0 2.2Å - 2012-06-27
Ion transport protein (67%), Sodium ion transport-associated (1%) (view alignment) (P83476) 6N4I_D 44.14 6.0E-11 3.5Å 6OU 2019-01-23
Ion transport protein (5%) (view alignment) SCN5A (Q14524) CALM3 (P0DP25) HUMAN 4OVN_F 100 0 2.798Å - 2014-12-03
Ion transport protein (5%) (view alignment) SCN5A (Q14524) CALM3 (P0DP25) HUMAN 4OVN_I 100 0 2.798Å - 2014-12-03
Ion transport protein (100%), Cytoplasmic domain of voltage-gated Na+ ion channel (7%), Sodium ion transport-associated (22%) (view alignment) SCN4A (P35499) SCN1B (Q07699) HUMAN 6AGF_A 76.39 2.0E-106 3.2Å 9Z9 NAG BMA 6OU 2018-10-10
Ion transport protein (100%), Cytoplasmic domain of voltage-gated Na+ ion channel (100%), Sodium ion transport-associated (16%) (view alignment) SCN9A (Q15858) SCN1B (Q07699), SCN2B (O60939) HUMAN 6J8I_A 74.03 0 3.2Å NAG 9SR 2019-02-27
Ion transport protein (100%), Cytoplasmic domain of voltage-gated Na+ ion channel (21%), Sodium ion transport-associated (16%) (view alignment) (D0E0C2), SCN9A (Q15858) (P01484) AMERICAN COCKROACH, HUMAN 6NT4_A 45.89 9.0E-56 3.5Å Y01 NAG BMA LHG PEE L0A 2019-02-20
Ion transport protein (5%) (view alignment) SCN5A (Q14524) CALM3 (P0DP25) HUMAN 4OVN_H 100 0 2.798Å - 2014-12-03
(view alignment) SCN5A (Q14524) CALM3 (P0DP25) HUMAN 4DJC_B 100 0 1.35Å - 2012-02-22
(view alignment) SCN5A (Q14524) CALM3 (P0DP25) HUMAN 2L53_B 100 0 - 2011-01-05
Ion transport protein (67%), Sodium ion transport-associated (1%) (view alignment) SCN9A (Q15858), (A8EVM5) (P83476) HUMAN 6N4Q_C 44.14 6.0E-11 3.6Å - 2019-01-23
Ion transport protein (5%) (view alignment) SCN4A (P35499) Calm1 (P0DP29) HUMAN 6MC9_A 75.46 5.0E-72 3.3Å - 2019-04-10
Ion transport protein (100%), Cytoplasmic domain of voltage-gated Na+ ion channel (100%), Sodium ion transport-associated (16%) (view alignment) SCN9A (Q15858) SCN1B (Q07699), SCN2B (O60939) HUMAN 6J8G_A 74.03 0 3.2Å NAG 9SL 2019-02-27
Ion transport protein (5%) (view alignment) SCN5A (Q14524) CALM3 (P0DP25), FGF12 (P61328) HUMAN 4JQ0_D 100 0 3.8Å - 2014-05-21
Ion transport protein (67%), Sodium ion transport-associated (1%) (view alignment) SCN9A (Q15858), (A8EVM5) (P83476) HUMAN 6N4R_C 44.14 6.0E-11 4.2Å - 2019-01-23
Ion transport protein (5%) (view alignment) SCN2A (Q99250) CALM3 (P0DP25), FGF13 (Q92913) HUMAN 4JPZ_H 76.4 4.0E-73 3.02Å - 2014-04-16
Ion transport protein (5%) (view alignment) SCN5A (Q14524) CALM3 (P0DP25) HUMAN 4OVN_J 100 0 2.798Å - 2014-12-03
Ion transport protein (67%), Sodium ion transport-associated (1%) (view alignment) (P83476) 6N4I_C 44.14 6.0E-11 3.5Å 6OU 2019-01-23
Ion transport protein (5%) (view alignment) SCN4A (P35499) Calm1 (P0DP29) HUMAN 6MBA_A 76.83 1.0E-72 1.799Å - 2019-04-10
Ion transport protein (67%), Sodium ion transport-associated (1%) (view alignment) SCN9A (Q15858), (A8EVM5) (P83476) HUMAN 6N4Q_B 44.14 6.0E-11 3.6Å - 2019-01-23
Ion transport protein (100%), Sodium ion transport-associated (16%) (view alignment) (D0E0C2) - AMERICAN COCKROACH 5X0M_A 43.93 7.0E-56 3.8Å NAG BMA 2017-03-08
(view alignment) SCN5A (Q14524) CALM1 (P0DP23) HUMAN 6MUD_B 100 0 2.69Å - 2019-05-08
Ion transport protein (67%), Sodium ion transport-associated (1%) (view alignment) SCN9A (Q15858), (A8EVM5) (P83476) HUMAN 6N4Q_D 44.14 6.0E-11 3.6Å - 2019-01-23
Ion transport protein (5%) (view alignment) SCN5A (Q14524) - HUMAN 2KBI_A 100 0 - 2008-12-23
Ion transport protein (67%), Sodium ion transport-associated (1%) (view alignment) (P83476) 6N4I_A 44.14 6.0E-11 3.5Å 6OU 2019-01-23
Ion transport protein (67%), Sodium ion transport-associated (1%) (view alignment) SCN9A (Q15858), (A8EVM5) (P83476) HUMAN 6N4R_B 44.14 6.0E-11 4.2Å - 2019-01-23
Ion transport protein (67%), Sodium ion transport-associated (1%) (view alignment) (P83476) 6N4I_B 44.14 6.0E-11 3.5Å 6OU 2019-01-23
Ion transport protein (2%) (view alignment) SCN5A (Q14524) CALM3 (P0DP25) HUMAN 5DBR_C 100 0 2.25Å - 2017-02-22
Ion transport protein (5%) (view alignment) SCN5A (Q14524) CALM3 (P0DP25) HUMAN 4OVN_G 100 0 2.798Å - 2014-12-03
Ion transport protein (100%), Cytoplasmic domain of voltage-gated Na+ ion channel (100%), Sodium ion transport-associated (19%) (view alignment) SCN2A (Q99250) (P0C195), SCN2B (O60939) HUMAN 6J8E_A 75.39 0 3Å 9Z9 NAG BMA 2019-02-27
Ion transport protein (67%), Sodium ion transport-associated (1%) (view alignment) SCN9A (Q15858), (A8EVM5) (P83476) HUMAN 6N4Q_A 44.14 6.0E-11 3.6Å - 2019-01-23
Ion transport protein (100%), Sodium ion transport-associated (16%) (view alignment) (D0E0C2) (P49126) AMERICAN COCKROACH 6A91_A 43.93 7.0E-56 3.2Å PC1 NAG 9SL 2018-08-08
Ion transport protein (100%), Cytoplasmic domain of voltage-gated Na+ ion channel (8%), Sodium ion transport-associated (13%) (view alignment) (P02719) (A0A1L3MZ94) ELECTRIC EEL 5XSY_A 65.83 7.0E-90 4Å NAG BMA 2017-08-09
Ion transport protein (100%), Cytoplasmic domain of voltage-gated Na+ ion channel (21%), Sodium ion transport-associated (16%) (view alignment) (D0E0C2), SCN9A (Q15858) - AMERICAN COCKROACH, HUMAN 6NT3_A 45.89 9.0E-56 3.4Å Y01 NAG BMA LHG PEE L0A 2019-02-20
Ion transport protein (100%), Cytoplasmic domain of voltage-gated Na+ ion channel (100%), Sodium ion transport-associated (16%) (view alignment) SCN9A (Q15858) SCN1B (Q07699), SCN2B (O60939) HUMAN 6J8H_A 74.03 0 3.2Å NAG 9SL 2019-02-27