Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
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Ligand Efficiency Plot
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Interaction Network
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Gene Copy Number Variation
RNAi
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SCN5A (Q14524) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 07/05/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 07/05/2019)


Chains assessed9
Chains with at least one site assessed as druggable using the strict criteria2
Chains with at least one site assessed as druggable using the relaxed criteria7


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4DCK_A Sodium channel protein type 5 subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.32 65.5 43.7 Yes No
2 empty 1.83 72.5 21.2 No No
3 empty 2.17 66 13 No No
4 empty 1.65 71 13.5 No No
5 empty 2.63 69.3 11.3 No No
6 empty 1.93 66.7 8.9 No No
7 empty 2.38 62.5 9.5 No No
8 empty 2.3 52 10 No No
9 empty 2.48 66.3 10.7 No No
10 empty 2.42 60 12.1 No No
4OVN_F Sodium channel protein type 5 subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.52 67.5 33.7 Yes No
2 empty 2.29 68.6 35.8 No No
3 empty 2.1 65.8 11.9 No No
4 empty 2.07 63.3 12.2 No No
5 empty 2.27 58.5 14.5 No No
6 empty 2.13 55.3 10.5 No No
7 empty 2.5 57.6 9.8 No No
8 empty 1.86 56.1 9.5 No No
9 empty 1.86 59.1 8.7 No No
10 empty 2.32 53.8 9.7 No No
4OVN_I Sodium channel protein type 5 subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.4 62.2 39.8 Yes No
2 empty 2.15 74.4 28 No No
3 empty 2.26 69.6 19.9 No No
4 empty 2.34 52.1 15.4 No No
5 empty 2.29 52.1 8.7 No No
6 empty 2.27 65.1 10.3 No No
7 empty 2.72 50.9 7.7 No No
8 empty 1.69 52 10.7 No No
9 empty 2.67 54.9 8.1 No No
10 empty 2.85 63.2 7.5 No No
4OVN_H Sodium channel protein type 5 subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.61 68.2 36.4 Yes Yes
2 empty 2.02 67.6 28.6 No No
3 empty 2.34 69.3 19.1 No No
4 empty 2.03 61.5 11.7 No No
5 empty 2.49 55.1 12.2 No No
6 empty 2.36 59.3 8.1 No No
7 empty 1.79 53.3 8.5 No No
8 empty 2.5 65.9 10.8 No No
9 empty 2.62 49.7 9.1 No No
10 empty 2.02 61.3 8 No No
2L53_B Sodium channel protein type 5 subunit alpha No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 57.9 21.8 No No
2 empty 2.15 68.1 9.9 No No
3 empty 1.87 59.2 8.4 No No
4 empty 2.71 60.3 8.7 No No
5 empty 2.68 53.6 5 No No
6 empty 1.52 56.5 4.8 No No
4JQ0_D Sodium channel protein type 5 subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.56 71.4 33.8 Yes Yes
2 empty 1.22 58.8 17.3 No No
3 empty 1.67 65.3 9.6 No No
4 empty 1.99 65.2 10.2 No No
5 empty 1.98 62.4 11.4 No No
6 empty 1.79 65.2 6.8 No No
7 empty 2.08 65.8 6.8 No No
8 empty 2.04 76.5 5.9 No No
9 empty 1.52 65.7 0 No No
10 empty 2.9 55.4 6 No No
4OVN_J Sodium channel protein type 5 subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.47 65.5 34.1 Yes No
2 empty 2.07 68.7 36.1 No No
3 empty 2.15 68.9 15.7 No No
4 empty 2.28 55.7 15 No No
5 empty 2.14 63.7 13.7 No No
6 empty 2.4 58.1 15.3 No No
7 empty 2.67 73.5 7 No No
8 empty 1.97 62.8 6.9 No No
9 empty 1.53 62.8 7.3 No No
10 empty 2.33 62.8 6.8 No No
2KBI_A Sodium channel protein type 5 subunit alpha No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 50.6 11.3 No No
2 empty 2.23 61.8 14.6 No No
3 empty 2.13 63.7 13.3 No No
4 empty 2.09 55.2 20.5 No No
5 empty 2.22 50.8 11.6 No No
6 empty 2.23 72.5 11.3 No No
7 empty 2.69 68.4 9.5 No No
8 empty 2.37 57.5 11.6 No No
9 empty 2.88 63.7 11.4 No No
10 empty 1.77 70.3 6.2 No No
4OVN_G Sodium channel protein type 5 subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.46 65.4 38.1 Yes No
2 empty 2.2 65.4 19.6 No No
3 empty 1.84 69.6 14.6 No No
4 empty 2.25 72 15.8 No No
5 empty 1.94 63.4 13.9 No No
6 empty 2.32 59.2 10.3 No No
7 empty 2.75 60.8 12.6 No No
8 empty 3.01 65.2 9 No No
9 empty 2.17 55.8 8.5 No No
10 empty 2.92 71.3 6.8 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed2
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria0

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2KBI_A (3140674) Sodium channel protein type 5 subunit alpha Transmembrane beta-barrels, Porins, Porin No No
2L53_B (3580069) Sodium channel protein type 5 subunit alpha PFAM, PFAM, PFAM IQ No No
Ligand-based Druggability Score: 1.2
Ligand-based Druggability Score Percentile: 92%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


SCN5A is involved in 21 interactions in the network.


Druggability
Overall Druggability Percentile: 95.08
Druggability for Cancer Therapeutics: 91.00
Druggability for Other Therapeutics: 97.54
Cancer-Associated
Cancer-associated percentile : 74.82
Network Articulation Point
Is SCN5A critical for communication in the network?


Detailed Graph Legend:Help