Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GAMT (Q14353) - Overview - Molecular Target Synopsis

Protein


GAMT, Guanidinoacetate N-methyltransferase
Enzyme Classification 2.1.1.2
UniProt Q14353

Also Known as GAMT_HUMAN, GAMT

Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor (PubMed:26003046, PubMed:24415674, PubMed:26319512). Important in nervous system development (PubMed:24415674). Monomer.

3ORH
HUMAN GUANIDINOACETATE N-METHYLTRANSFERASE WITH SAH
RCSB/PDB
Inspect Structure
See all 3D Structures for GAMT

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: GAMT is active in the following subcellular-locations: cytoplasm, cytosol, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GAMT has gain in 0 cell-lines, loss in 4 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HCT_15, HCT_116, MOLT_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HuH-7, C3A, JHH-7

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, IMR-90

(see details)

3D Structures


For GAMT there are:
1 structures (4 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis