FRG1 (Q14331) - Overview - Molecular Target Synopsis
FRG1, Protein FRG1
Also Known as FRG1_HUMAN, FRG1
Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B. Homodimer and homotetramer in solution. Identified in the spliceosome C complex. Interacts with KMT5B (via C-terminus). Interacts (via N-terminus) with KPNA2 and NXF1/TAP. Interacts with F-actin with a stoichiometry of 2:1.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
UniProt: FRG1 is active in the following subcellular-locations: cajal body, cytoplasm, myofibril, nucleolus, nucleus, sarcomere, z line.
GO terms: FRG1 is active in the following subcellular-locations: Cajal body, catalytic step 2 spliceosome, nucleolus, striated muscle dense body, Z disc.