Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FRG1 (Q14331) - Overview - Molecular Target Synopsis

Protein


FRG1, Protein FRG1
UniProt Q14331

Also Known as FRG1_HUMAN, FRG1

Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B. Homodimer and homotetramer in solution. Identified in the spliceosome C complex. Interacts with KMT5B (via C-terminus). Interacts (via N-terminus) with KPNA2 and NXF1/TAP. Interacts with F-actin with a stoichiometry of 2:1.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: FRG1 is active in the following subcellular-locations: cajal body, cytoplasm, myofibril, nucleolus, nucleus, sarcomere, z line.
GO terms: FRG1 is active in the following subcellular-locations: Cajal body, catalytic step 2 spliceosome, nucleolus, striated muscle dense body, Z disc.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FRG1 has gain in 0 cell-lines, loss in 10 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, CCRF_CEM, MOLT_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-436, HEL, OCI-M1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, K562

(see details)

3D Structures


At greater than 90% identity similarity to FRG1 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis