Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
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Ligand Efficiency Plot
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PTK2B (Q14289) - Domains And Structures - Molecular Target Synopsis

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Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 4K9Y_A 59.78 1.0E-88 2Å K9Y 2013-09-11
Protein tyrosine kinase (90%) (view alignment) Ephb2 (P54763) - HOUSE MOUSE 2HEN_C 41.45 5.0E-52 2.6Å ADP 2007-02-13
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 4Q9S_A 60.52 2.0E-88 2.07Å 30G 2014-07-02
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - HOUSE MOUSE 1IEP_A 38.03 4.0E-51 2.1Å STI 2001-04-18
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 2V7A_A 38.03 4.0E-51 2.5Å 627 2007-09-18
FERM N-terminal domain (100%), FERM central domain (100%) (view alignment) PTK2 (Q00944) - CHICKEN 2J0M_A 45.28 1.0E-88 2.8Å - 2007-07-03
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 4D5H_B 60.15 6.0E-88 1.75Å - 2015-02-18
Protein tyrosine kinase (90%) (view alignment) EPHB1 (P54762) - HUMAN 3ZFX_I 42.31 3.0E-54 2.499Å - 2014-01-08
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - MOUSE 3MS9_A 38.03 4.0E-51 1.8Å STI MS9 2010-05-26
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - MOUSE 3DK7_A 38.1 7.0E-51 2.01Å SX7 2008-07-29
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 4D4S_B 60.15 6.0E-88 2Å BI9 2015-02-18
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 6NPU_A 38.03 4.0E-51 2.33Å STI KWV 2019-03-13
Protein tyrosine kinase (89%) (view alignment) EPHB4 (P54760) - HUMAN 2YN8_A 41.13 9.0E-51 2.11Å STU 2013-10-23
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 4P4C_A 40.77 6.0E-52 1.599Å 25Q 2014-08-13
Protein tyrosine kinase (91%) (view alignment) ABL1 (P00519) - HUMAN 4XEY_A 40.4 2.0E-51 2.89Å 1N1 2015-04-01
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 2G2F_B 38.03 6.0E-51 2.7Å AGS 2006-05-23
Focal adhesion targeting region (100%) (view alignment) PTK2B (Q14289) - HUMAN 3GM2_A 100 0 2.7Å - 2009-05-05
Protein tyrosine kinase (100%) (view alignment) PTK2B (Q14289) - HUMAN 5TO8_A 100 0 1.98Å 7FM 2016-12-21
Focal adhesion targeting region (100%) (view alignment) PTK2B (Q14289) LPXN (O60711) HUMAN 4XEV_D 100 0 2Å - 2015-12-30
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 2HIW_A 38.03 6.0E-51 2.2Å 7MP 2006-08-22
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 6GCW_B 60.15 6.0E-88 2Å EUQ 2019-05-01
Protein tyrosine kinase (90%) (view alignment) ERBB4 (Q15303) - HUMAN 2R4B_A 41.13 6.0E-53 2.4Å GW7 2008-03-18
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 4I4E_A 60.52 2.0E-88 1.55Å 1BQ 2013-03-06
FERM N-terminal domain (100%), FERM central domain (100%), Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 2J0J_A 51.29 0 2.8Å 4ST 2007-06-26
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 2G2I_B 38.03 6.0E-51 3.1Å ADP 2006-05-23
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 2QO2_A 40.77 6.0E-52 1.6Å - 2007-08-21
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 4GU6_A 60.52 2.0E-88 1.95Å 10N 2013-09-04
FERM N-terminal domain (100%), FERM central domain (100%) (view alignment) PTK2 (Q05397) - HUMAN 4NY0_C 45.74 2.0E-89 2.8Å - 2014-03-12
FERM N-terminal domain (100%), FERM central domain (100%), Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 2J0K_B 51.14 0 3Å 4ST 2007-07-03
Protein tyrosine kinase (100%) (view alignment) - 4CSV_A 40.66 5.0E-51 2.05Å STI 2015-03-04
Protein tyrosine kinase (90%) (view alignment) ERBB4 (Q15303) - HUMAN 3BCE_A 41.13 6.0E-53 2.5Å - 2008-02-12
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 3FXX_A 40.77 7.0E-52 1.7Å ANP 2009-02-03
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - MOUSE 6HD4_B 38.03 4.0E-51 2.03Å FYW STI 2018-10-24
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 4KAO_A 60.52 2.0E-88 2.39Å KAO 2013-09-11
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - MOUSE 3K5V_A 38.03 4.0E-51 1.74Å STJ STI 2010-01-19
FERM N-terminal domain (100%), FERM central domain (100%) (view alignment) PTK2 (Q00944) - CHICKEN 2AEH_A 45.28 1.0E-88 2.5Å - 2005-10-18
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 4KAB_B 59.78 1.0E-88 2.71Å 4KA 2013-09-11
FERM N-terminal domain (100%), FERM central domain (100%) (view alignment) PTK2 (Q05397) - HUMAN 4NY0_B 45.74 2.0E-89 2.8Å - 2014-03-12
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 4I4F_A 60.52 2.0E-88 1.75Å 1BR 2013-02-06
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 2G1T_D 38.03 6.0E-51 1.8Å - 2006-05-23
Protein tyrosine kinase (91%) (view alignment) ABL1 (P00519) - HUMAN 1OPL_B 40 6.0E-51 3.4Å P16 2003-04-08
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 6GCX_A 60.15 6.0E-88 1.55Å EUW 2019-05-01
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - 3DZQ_A 40.77 6.0E-52 1.75Å IFC 2008-08-26
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 2QOF_A 40.77 6.0E-52 1.2Å - 2007-08-21
Protein tyrosine kinase (90%) (view alignment) ERBB4 (Q15303) - HUMAN 3BBW_B 41.13 6.0E-53 4Å - 2008-02-12
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - HOUSE MOUSE 2QOH_B 38.03 4.0E-51 1.95Å P3Y 2007-09-18
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 6NPE_B 38.03 4.0E-51 2.15Å 2PE KWD STI 2019-03-13
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - MOUSE 3MS9_B 38.03 4.0E-51 1.8Å STI MS9 2010-05-26
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 4ZOG_A 38.03 5.0E-51 2.3Å VX6 2016-09-14
Protein tyrosine kinase (90%) (view alignment) Ephb2 (P54763) - HOUSE MOUSE 2HEN_A 41.45 5.0E-52 2.6Å ADP 2007-02-13
Protein tyrosine kinase (89%) (view alignment) EPHB4 (P54760) - HUMAN 4AW5_A 41.56 8.0E-51 2.33Å 30K 2012-08-01
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 2J0L_A 60.52 4.0E-88 2.3Å ANP 2007-06-26
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 4K8A_B 59.78 1.0E-88 2.91Å K8A 2013-09-11
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 2J0M_B 60.52 3.0E-88 2.8Å 4ST 2007-07-03
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 4EBV_A 60.52 2.0E-88 1.67Å 0O7 2012-08-22
Focal adhesion targeting region (100%) (view alignment) PTK2B (Q14289) PXN (P49023) HUMAN 3U3F_C 100 0 3.1Å - 2012-10-24
FERM N-terminal domain (100%), FERM central domain (100%) (view alignment) PTK2 (Q00944) - CHICKEN 2AEH_B 45.28 1.0E-88 2.5Å - 2005-10-18
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 3FY2_A 40.77 7.0E-52 1.78Å - 2009-02-03
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 3BZ3_A 60.52 3.0E-88 2.2Å YAM 2008-04-01
Protein tyrosine kinase (100%) (view alignment) PTK2B (Q14289) - HUMAN 5TOB_A 100 0 2.117Å YAM 2017-11-29
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 2GSF_A 40.77 6.0E-52 1.75Å - 2006-06-13
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - MOUSE 3KFA_B 38.03 4.0E-51 1.22Å B91 2009-12-22
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 2QOQ_A 40.77 6.0E-52 1.6Å ANP 2007-10-02
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 2JKM_A 60.52 4.0E-88 2.3Å BII 2008-09-09
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - MOUSE 3OXZ_A 38.03 5.0E-51 2.2Å 0LI 2010-12-15
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 4C7T_A 60.15 6.0E-88 2.05Å 5RI 2014-04-02
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 2JKK_A 60.15 6.0E-88 2Å BI9 2008-09-09
FERM N-terminal domain (100%), FERM central domain (100%) (view alignment) PTK2 (Q00944) - CHICKEN 4CYE_B 45.6 5.0E-90 3.2Å - 2014-04-23
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 2ETM_A 60.52 2.0E-88 2.3Å 7PY 2006-10-10
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 2QOI_A 40.77 6.0E-52 1.25Å - 2007-08-21
Protein tyrosine kinase (89%) (view alignment) Epha4 (Q03137) - HOUSE MOUSE 2HEL_A 42.79 2.0E-52 2.35Å - 2007-02-13
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - MOUSE 3OY3_A 38.03 3.0E-51 1.95Å XY3 2010-12-15
Protein tyrosine kinase (90%) (view alignment) EPHB1 (P54762) - HUMAN 3ZFX_H 42.31 3.0E-54 2.499Å - 2014-01-08
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - HOUSE MOUSE 1M52_B 38.03 4.0E-51 2.6Å P17 MES 2002-09-18
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - MOUSE 3K5V_B 38.03 4.0E-51 1.74Å STJ STI 2010-01-19
Protein tyrosine kinase (90%) (view alignment) ERBB4 (Q15303) - HUMAN 3BCE_C 41.13 6.0E-53 2.5Å - 2008-02-12
Protein tyrosine kinase (89%) (view alignment) EPHB4 (P54760) - HUMAN 3ZEW_B 41.56 4.0E-51 2.5Å STU 2013-12-25
Protein tyrosine kinase (90%) (view alignment) EPHB1 (P54762) - HUMAN 3ZFX_F 42.31 3.0E-54 2.499Å - 2014-01-08
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 4YC8_A 38.03 6.0E-51 2.9Å MES 4B7 2016-03-02
Protein tyrosine kinase (90%) (view alignment) ABL2 (P42684) - HUMAN 3GVU_A 42.36 3.0E-51 2.05Å STI 2009-04-21
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 2E2B_B 38.03 4.0E-51 2.2Å 406 2007-05-22
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 2QOB_A 40.77 7.0E-52 1.65Å - 2007-08-21
FERM N-terminal domain (100%), FERM central domain (100%) (view alignment) PTK2B (Q14289) - HUMAN 4EKU_A 100 0 3.25Å - 2012-04-25
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 2F4J_A 38.03 5.0E-51 1.9Å VX6 2006-01-24
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 6NPU_B 38.03 4.0E-51 2.33Å 2PE STI KWV 2019-03-13
Protein tyrosine kinase (100%) (view alignment) PTK2B (Q14289) - HUMAN 3H3C_A 100 0 2Å P1E 2009-05-26
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 4G2F_A 40.77 6.0E-52 1.699Å C07 2012-10-24
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 2QO9_A 40.77 6.0E-52 1.55Å ANP 2007-08-21
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - MOUSE 3DK7_B 38.1 7.0E-51 2.01Å SX7 2008-07-29
Protein tyrosine kinase (90%) (view alignment) EPHB1 (P54762) - HUMAN 5MJB_B 41.45 5.0E-52 2.23Å 7O3 2017-05-17
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 4GU9_B 59.78 1.0E-88 2.4Å 4GU 2013-09-04
Protein tyrosine kinase (90%) (view alignment) Abl1 (P00520) - MOUSE 3DK6_B 40.65 4.0E-51 2.016Å SX7 2008-07-29
Focal adhesion targeting region (100%) (view alignment) PTK2B (Q14289) PXN (P49023) HUMAN 3GM1_A 100 0 2.95Å - 2009-05-05
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 6GCR_A 60.15 6.0E-88 2.3Å EUW 2019-05-01
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 2QO7_A 40.77 6.0E-52 1.6Å ANP 2007-08-28
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 4D55_A 60.15 6.0E-88 2.3Å - 2015-02-18
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 3PXK_B 60.52 2.0E-88 1.79Å PXK 2011-12-21
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 4D4Y_A 60.15 6.0E-88 1.8Å - 2015-02-18
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - HOUSE MOUSE 1OPJ_B 38.03 4.0E-51 1.7Å STI 2003-04-08
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - MOUSE 3MSS_D 38.03 4.0E-51 1.95Å MS7 STI 2010-05-26
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 4D4S_A 60.15 6.0E-88 2Å - 2015-02-18
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - MOUSE 3DK3_B 37.68 1.0E-50 2.02Å SX7 2008-07-29
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 3UE4_B 38.03 6.0E-51 2.42Å DB8 2012-04-18
Protein tyrosine kinase (89%) (view alignment) Epha4 (Q03137) - MOUSE 2XYU_A 42.79 6.0E-52 2.117Å Q9G 2011-11-30
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 4D4V_B 60.15 6.0E-88 2.1Å KB8 2015-02-18
Protein tyrosine kinase (100%) (view alignment) PTK2B (Q14289) - HUMAN 4H1M_A 100 0 1.99Å 0YJ 2012-11-28
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 4D4R_A 60.15 6.0E-88 1.55Å - 2015-02-18
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 2QOD_A 40.77 6.0E-52 1.15Å - 2007-08-21
Protein tyrosine kinase (91%) (view alignment) ABL1 (P00519) - HUMAN 4XEY_B 40.4 2.0E-51 2.89Å 1N1 2015-04-01
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - MOUSE 6HD4_A 38.03 4.0E-51 2.03Å FYW STI 2018-10-24
FERM N-terminal domain (100%), FERM central domain (100%), Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 2J0K_A 51.14 0 3Å 4ST 2007-07-03
FERM N-terminal domain (100%), FERM central domain (100%) (view alignment) PTK2 (Q00944) - CHICKEN 6CB0_A 45.6 5.0E-90 1.97Å - 2019-02-06
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - MOUSE 3KF4_B 38.03 4.0E-51 1.9Å B90 2009-12-22
Protein tyrosine kinase (90%) (view alignment) ERBB4 (Q15303) - HUMAN 2R4B_B 41.13 6.0E-53 2.4Å GW7 2008-03-18
Protein tyrosine kinase (91%) (view alignment) ABL1 (P00519) - HUMAN 1OPL_A 40 6.0E-51 3.4Å P16 2003-04-08
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 2G2H_B 38.03 6.0E-51 1.95Å P16 2006-05-23
Protein tyrosine kinase (90%) (view alignment) ABL2 (P42684) - HUMAN 2XYN_A 42.36 3.0E-51 2.81Å VX6 2010-12-01
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 2G1T_A 38.03 6.0E-51 1.8Å - 2006-05-23
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 3PYY_A 38.03 4.0E-51 1.85Å 3YY STI 2011-03-09
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 4D58_A 60.15 6.0E-88 1.95Å - 2015-02-18
Protein tyrosine kinase (90%) (view alignment) Ephb2 (P54763) - HOUSE MOUSE 1JPA_A 41.88 7.0E-53 1.91Å ANP 2001-10-03
Protein tyrosine kinase (90%) (view alignment) ABL2 (P42684) - HUMAN 2XYN_B 42.36 3.0E-51 2.81Å VX6 2010-12-01
Protein tyrosine kinase (90%) (view alignment) EPHB1 (P54762) - HUMAN 5MJA_A 41.88 3.0E-53 2.14Å 7O3 2017-05-17
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 4D5K_B 60.15 6.0E-88 1.75Å - 2015-02-18
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 4GK4_A 40.77 6.0E-52 2.1Å L90 2013-01-23
Protein tyrosine kinase (100%) (view alignment) PTK2B (Q14289) - HUMAN 3FZT_A 100 0 1.95Å 4JZ 2009-03-31
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 2QON_A 40.77 3.0E-52 1.79Å - 2007-08-28
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 4D4R_B 60.15 6.0E-88 1.55Å - 2015-02-18
Focal adhesion targeting region (100%) (view alignment) PTK2B (Q14289) LPXN (O60711) HUMAN 4XEF_D 100 0 2.5Å - 2015-12-23
FERM N-terminal domain (100%), FERM central domain (100%) (view alignment) PTK2 (Q00944) - CHICKEN 3ZDT_A 44.53 1.0E-87 3.15Å - 2012-12-12
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 6I8Z_A 60.52 2.0E-88 1.99Å H82 2019-02-20
Protein tyrosine kinase (90%) (view alignment) ABL2 (P42684) - HUMAN 3HMI_A 42.36 3.0E-51 1.65Å DKI 2009-07-07
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 2E2B_A 38.03 4.0E-51 2.2Å 406 2007-05-22
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 2QOO_A 40.77 5.0E-52 1.25Å - 2007-08-28
FERM N-terminal domain (100%), FERM central domain (100%) (view alignment) PTK2 (Q00944) - CHICKEN 2AL6_A 45.6 5.0E-90 2.35Å - 2005-10-18
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - HOUSE MOUSE 6HD6_B 38.03 4.0E-51 2.3Å STI 2018-09-12
Protein tyrosine kinase (100%) (view alignment) PTK2B (Q14289) - HUMAN 3CC6_A 100 0 1.6Å - 2008-03-11
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 4WA9_A 38.03 6.0E-51 2.2Å AXI 2015-02-11
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - MOUSE 3MSS_A 38.03 4.0E-51 1.95Å MS7 STI 2010-05-26
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 4GU6_B 60.52 2.0E-88 1.95Å 10N 2013-09-04
Focal adhesion targeting region (100%) (view alignment) PTK2B (Q14289) PXN (P49024) HUMAN 4R32_A 100 0 3.5Å - 2014-09-17
Protein tyrosine kinase (90%) (view alignment) EPHB1 (P54762) - HUMAN 3ZFX_C 42.31 3.0E-54 2.499Å - 2014-01-08
Focal adhesion targeting region (100%) (view alignment) PTK2B (Q14289) PXN (P49023) HUMAN 3U3F_A 100 0 3.1Å - 2012-10-24
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 2G1T_C 38.03 6.0E-51 1.8Å - 2006-05-23
Protein tyrosine kinase (90%) (view alignment) EPHB1 (P54762) - HUMAN 3ZFX_A 42.31 3.0E-54 2.499Å - 2014-01-08
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - MOUSE 3IK3_A 38.03 3.0E-51 1.9Å 0LI 2009-11-03
Protein tyrosine kinase (90%) (view alignment) EPHB1 (P54762) - HUMAN 3ZFX_E 42.31 3.0E-54 2.499Å - 2014-01-08
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 4BRX_A 60.15 6.0E-88 2.05Å KGW 2013-07-24
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 2HIW_B 38.03 6.0E-51 2.2Å 7MP 2006-08-22
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - HOUSE MOUSE 1M52_A 38.03 4.0E-51 2.6Å P17 2002-09-18
FERM N-terminal domain (100%), FERM central domain (100%) (view alignment) PTK2 (Q00944) - CHICKEN 4CYE_A 45.6 5.0E-90 3.2Å - 2014-04-23
FERM N-terminal domain (100%), FERM central domain (100%) (view alignment) PTK2 (Q05397) - HUMAN 4NY0_D 45.74 2.0E-89 2.8Å - 2014-03-12
Protein tyrosine kinase (89%) (view alignment) EPHB4 (P54760) - HUMAN 3ZEW_A 41.56 4.0E-51 2.5Å STU 2013-12-25
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 3PYY_B 38.03 4.0E-51 1.85Å 2PE 3YY STI 2011-03-09
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 4KAB_A 59.78 1.0E-88 2.71Å 4KA 2013-09-11
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 4K8A_A 59.78 1.0E-88 2.91Å K8A 2013-09-11
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - MOUSE 3KFA_A 38.03 4.0E-51 1.22Å B91 2009-12-22
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 4GU9_A 59.78 1.0E-88 2.4Å 4GU 2013-09-04
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 2G2I_A 38.03 6.0E-51 3.1Å ADP 2006-05-23
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 4D4V_A 60.15 6.0E-88 2.1Å - 2015-02-18
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 4YC8_B 38.03 6.0E-51 2.9Å MES 4B7 2016-03-02
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 6NPV_B 38.03 4.0E-51 1.86Å 2PE KWP STI 2019-03-13
Protein tyrosine kinase (100%) (view alignment) PTK2B (Q14289) - HUMAN 3FZS_A 100 0 1.75Å B96 2009-03-31
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 4TWN_A 40.77 6.0E-52 1.71Å B96 2015-05-13
Protein tyrosine kinase (100%) (view alignment) PTK2B (Q14289) - HUMAN 4H1J_A 100 0 2Å 0YH 2012-11-28
Protein tyrosine kinase (89%) (view alignment) EPHB4 (P54760) - HUMAN 2YN8_B 41.13 9.0E-51 2.11Å STU 2013-10-23
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - MOUSE 3IK3_B 38.03 3.0E-51 1.9Å 0LI 2009-11-03
Focal adhesion targeting region (100%) (view alignment) PTK2B (Q14289) LPXN (O60711) HUMAN 4XEK_A 100 0 1.79Å - 2015-12-30
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 4EBW_A 60.52 2.0E-88 2.6Å 0PF 2012-07-25
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 6NPV_A 38.03 4.0E-51 1.86Å KWP STI 2019-03-13
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - HOUSE MOUSE 1FPU_A 38.03 4.0E-51 2.4Å PRC 2000-09-20
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 3PXK_A 60.52 2.0E-88 1.79Å PXK 2011-12-21
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 1MP8_A 60.52 2.0E-88 1.6Å ADP 2003-09-16
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - HOUSE MOUSE 2QOH_A 38.03 4.0E-51 1.95Å P3Y 2007-09-18
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 2G2F_A 38.03 6.0E-51 2.7Å - 2006-05-23
Protein tyrosine kinase (100%) (view alignment) PTK2B (Q14289) - HUMAN 3ET7_A 100 0 2.7Å 349 2009-06-23
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - HOUSE MOUSE 1IEP_B 38.03 4.0E-51 2.1Å STI 2001-04-18
Focal adhesion targeting region (100%) (view alignment) PTK2B (Q14289) LPXN (O60711) HUMAN 4XEF_A 100 0 2.5Å - 2015-12-23
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 4P5Z_A 40.77 6.0E-52 2Å Q7M 2014-08-13
Focal adhesion targeting region (100%) (view alignment) PTK2B (Q14289) PXN (P49023) HUMAN 3U3F_B 100 0 3.1Å - 2012-10-24
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 2JKQ_A 60.52 3.0E-88 2.6Å VG8 2008-09-09
Protein tyrosine kinase (89%) (view alignment) EPHA5 (P54756) - HUMAN 2R2P_A 42.36 5.0E-52 2.4Å - 2007-09-25
Protein tyrosine kinase (90%) (view alignment) ERBB4 (Q15303) - HUMAN 3BBW_A 41.13 6.0E-53 4Å - 2008-02-12
Focal adhesion targeting region (100%) (view alignment) PTK2B (Q14289) - HUMAN 3GM3_A 100 0 2.6Å - 2009-05-05
Protein tyrosine kinase (90%) (view alignment) ERBB4 (Q15303) - HUMAN 3BCE_B 41.13 6.0E-53 2.5Å - 2008-02-12
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 4ZOG_B 38.03 5.0E-51 2.3Å MES VX6 2016-09-14
Protein tyrosine kinase (100%) (view alignment) PTK2B (Q14289) - HUMAN 3FZP_A 100 0 2.1Å AGS 2009-03-31
Focal adhesion targeting region (100%) (view alignment) PTK2B (Q14289) LPXN (O60711) HUMAN 4XEV_A 100 0 2Å - 2015-12-30
Protein tyrosine kinase (100%) (view alignment) PTK2B (Q14289) - HUMAN 3FZR_A 100 0 2.7Å 3JZ 2009-03-31
Protein tyrosine kinase (91%) (view alignment) ABL1 (P00519) - HUMAN 5MO4_A 40 4.0E-51 2.166Å NIL AY7 2017-04-05
Protein tyrosine kinase (90%) (view alignment) EPHB1 (P54762) - HUMAN 5MJB_A 41.45 5.0E-52 2.23Å 7O3 2017-05-17
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 2G2H_A 38.03 6.0E-51 1.95Å P16 2006-05-23
Protein tyrosine kinase (90%) (view alignment) Ephb2 (P54763) - HOUSE MOUSE 2HEN_D 41.45 5.0E-52 2.6Å ADP 2007-02-13
Protein tyrosine kinase (90%) (view alignment) EPHB1 (P54762) - HUMAN 3ZFX_B 42.31 3.0E-54 2.499Å - 2014-01-08
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 4WA9_B 38.03 6.0E-51 2.2Å AXI 2015-02-11
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 2JKO_A 60.15 6.0E-88 1.65Å BIJ 2008-09-09
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - HOUSE MOUSE 1FPU_B 38.03 4.0E-51 2.4Å PRC 2000-09-20
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - MOUSE 3MSS_B 38.03 4.0E-51 1.95Å MS7 STI 2010-05-26
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 2QOK_A 40.34 1.0E-51 1.2Å - 2007-08-28
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - MOUSE 3MSS_C 38.03 4.0E-51 1.95Å MS7 STI 2010-05-26
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 4D5H_A 60.15 6.0E-88 1.75Å 9RM 2015-02-18
Protein tyrosine kinase (90%) (view alignment) ABL1 (P00519) - HUMAN 2FO0_A 40.24 5.0E-51 2.27Å P16 2006-03-21
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 2IJM_B 60.52 2.0E-88 2.187Å ADP 2007-08-14
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 2ETM_B 60.52 2.0E-88 2.3Å 7PY 2006-10-10
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 2G1T_B 38.03 6.0E-51 1.8Å - 2006-05-23
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - MOUSE 3KF4_A 38.03 4.0E-51 1.9Å B90 2009-12-22
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 2IJM_A 60.52 2.0E-88 2.187Å ATP 2007-08-14
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q05397) - HUMAN 4KAO_B 60.52 2.0E-88 2.39Å KAO 2013-09-11
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 4GK3_A 40.77 6.0E-52 1.898Å L87 2013-01-23
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 4D58_B 60.15 6.0E-88 1.95Å BI9 2015-02-18
FERM N-terminal domain (100%), FERM central domain (100%) (view alignment) PTK2 (Q05397) - HUMAN 4NY0_A 45.74 2.0E-89 2.8Å - 2014-03-12
Protein tyrosine kinase (100%) (view alignment) PTK2B (Q14289) - HUMAN 3FZO_A 100 0 2.2Å - 2009-03-31
Protein tyrosine kinase (90%) (view alignment) EPHA7 (Q15375) - HUMAN 3DKO_A 40.69 6.0E-51 2Å IHZ 2008-08-19
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 6GCW_A 60.15 6.0E-88 2Å EUQ 2019-05-01
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 4TWO_A 40.77 6.0E-52 2.05Å 37W 2015-05-13
FERM N-terminal domain (100%), FERM central domain (100%) (view alignment) PTK2 (Q00944) - CHICKEN 6CB0_B 45.6 5.0E-90 1.97Å - 2019-02-06
Focal adhesion targeting region (100%) (view alignment) PTK2B (Q14289) - HUMAN 2LK4_A 100 0 - 2012-10-10
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - HOUSE MOUSE 1OPJ_A 38.03 4.0E-51 1.7Å STI 2003-04-08
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 3UE4_A 38.03 6.0E-51 2.42Å DB8 2012-04-18
Focal adhesion targeting region (100%) (view alignment) PTK2B (Q14289) PXN (P49023) HUMAN 3GM1_B 100 0 2.95Å - 2009-05-05
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 4P5Q_A 40.77 6.0E-52 1.35Å Q0B 2014-08-13
Protein tyrosine kinase (90%) (view alignment) EPHB1 (P54762) - HUMAN 3ZFX_G 42.31 3.0E-54 2.499Å - 2014-01-08
Protein tyrosine kinase (90%) (view alignment) EPHA7 (Q15375) - HUMAN 2REI_A 40.69 6.0E-51 1.6Å - 2007-10-23
Protein tyrosine kinase (90%) (view alignment) Abl1 (P00520) - MOUSE 3DK6_A 40.65 4.0E-51 2.016Å SX7 2008-07-29
Protein tyrosine kinase (90%) (view alignment) Ephb2 (P54763) - HOUSE MOUSE 1JPA_B 41.88 7.0E-53 1.91Å ANP 2001-10-03
Protein tyrosine kinase (90%) (view alignment) EPHB1 (P54762) - HUMAN 3ZFX_D 42.31 3.0E-54 2.499Å - 2014-01-08
Protein tyrosine kinase (89%) (view alignment) Epha4 (Q03137) - HOUSE MOUSE 2Y6M_A 42.79 5.0E-52 1.7Å - 2011-11-02
Protein tyrosine kinase (91%) (view alignment) Abl1 (P00520) - HOUSE MOUSE 1OPK_A 40 6.0E-51 1.8Å P16 2003-04-08
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - HOUSE MOUSE 6HD6_A 38.03 4.0E-51 2.3Å FYH STI 2018-09-12
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 2QOL_A 40.34 2.0E-51 1.07Å - 2007-08-28
FERM N-terminal domain (100%), FERM central domain (100%) (view alignment) PTK2 (Q00944) - CHICKEN 2AL6_B 45.6 5.0E-90 2.35Å - 2005-10-18
Protein tyrosine kinase (90%) (view alignment) EPHB1 (P54762) - HUMAN 5MJA_B 41.88 3.0E-53 2.14Å 7O3 2017-05-17
Protein tyrosine kinase (90%) (view alignment) ERBB4 (Q15303) - HUMAN 3BBT_B 41.13 6.0E-53 2.8Å FMM 2008-02-12
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - HOUSE MOUSE 2HZN_A 38.03 4.0E-51 2.7Å KIN 2007-01-16
Protein tyrosine kinase (90%) (view alignment) EPHB2 (P29323) - HUMAN 3ZFM_A 41.88 6.0E-53 2.27Å - 2014-01-08
Protein tyrosine kinase (89%) (view alignment) Epha4 (Q03137) - HOUSE MOUSE 2Y6O_A 42.79 5.0E-52 1.54Å 1N1 2011-11-02
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 6NPE_A 38.03 4.0E-51 2.15Å KWD STI 2019-03-13
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 4D4Y_B 60.15 6.0E-88 1.8Å - 2015-02-18
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 2QOC_A 40.77 7.0E-52 1.25Å ANP 2007-08-21
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - MOUSE 3OY3_B 38.03 3.0E-51 1.95Å XY3 2010-12-15
Protein tyrosine kinase (91%) (view alignment) EPHA3 (P29320) - HUMAN 4GK2_A 40.77 6.0E-52 2.195Å L66 2013-01-23
Protein tyrosine kinase (100%) (view alignment) Abl1 (P00520) - HOUSE MOUSE 2Z60_A 38.03 3.0E-51 1.95Å P3Y 2007-09-18
Protein tyrosine kinase (100%) (view alignment) ABL1 (P00519) - HUMAN 2V7A_B 38.03 4.0E-51 2.5Å 627 2007-09-18
Protein tyrosine kinase (100%) (view alignment) PTK2 (Q00944) - CHICKEN 4D5K_A 60.15 6.0E-88 1.75Å - 2015-02-18
Focal adhesion targeting region (100%) (view alignment) PTK2B (Q14289) PXN (P49023) HUMAN 3U3F_D 100 0 3.1Å - 2012-10-24
Protein tyrosine kinase (90%) (view alignment) ERBB4 (Q15303) - HUMAN 3BBT_D 41.13 6.0E-53 2.8Å FMM 2008-02-12
Protein tyrosine kinase (90%) (view alignment) ABL2 (P42684) - HUMAN 2XYN_C 42.36 3.0E-51 2.81Å VX6 2010-12-01
Protein tyrosine kinase (90%) (view alignment) Ephb2 (P54763) - HOUSE MOUSE 2HEN_B 41.45 5.0E-52 2.6Å ADP 2007-02-13
FERM N-terminal domain (100%), FERM central domain (100%) (view alignment) PTK2 (Q00944) - CHICKEN 3ZDT_B 44.53 1.0E-87 3.15Å - 2012-12-12
Protein tyrosine kinase (100%) (view alignment) - 4UEU_A 40.66 5.0E-51 2.95Å ACP 2015-02-18