Molecular Target Synopsis
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PTK2B (Q14289) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 07/05/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 07/05/2019)


Chains assessed28
Chains with at least one site assessed as druggable using the strict criteria13
Chains with at least one site assessed as druggable using the relaxed criteria21


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5TO8_A Protein-tyrosine kinase 2-beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.07 70.5 39 Yes Yes
2 empty 2.1 63 31.2 No No
3 empty 1.69 66 25.4 No No
4 empty 2.31 60.7 19.9 No No
5 empty 2.38 59.7 20.2 No No
6 empty 2.19 67 9.8 No No
7 empty 2.09 57.7 11.5 No No
8 empty 2.33 66.9 10.3 No No
9 empty 2.4 73.2 11 No No
10 empty 1.67 63.4 9.3 No No
3GM2_A Protein-tyrosine kinase 2-beta No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 65.6 18.6 No No
2 empty 2.11 60.4 18.7 No No
3 empty 1.49 63.7 15.8 No No
4 empty 2.05 67.6 10.8 No No
5 empty 1.84 69.6 10.9 No No
6 empty 1.81 66.7 9.6 No No
7 empty 1.97 64.7 9.6 No No
8 empty 1.9 73 10.6 No No
9 empty 1.97 75.2 6.9 No No
10 empty 1.78 49.2 7.1 No No
4XEV_D Protein-tyrosine kinase 2-beta Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 76.8 13.9 Yes No
2 empty 2.08 65.9 15.4 No No
3 empty 1.8 66.1 13.4 No No
4 empty 2.29 64 22.1 No No
5 empty 2.07 63.5 16.1 No No
6 empty 2.33 74.4 7.1 No No
7 empty 2.74 54.7 10 No No
8 empty 2.13 61.2 7.8 No No
9 empty 2.15 63.4 7.5 No No
10 empty 2.1 76.4 6.5 No No
3U3F_C Protein-tyrosine kinase 2-beta No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 62.2 19.6 No No
2 empty 2.13 55 17.4 No No
3 empty 1.98 67.9 10.6 No No
4 empty 1.72 69.8 11.8 No No
5 empty 2.28 54.3 15.3 No No
6 empty 1.36 66.5 10.1 No No
7 empty 2.19 65 8.1 No No
8 empty 2.2 70.8 7.5 No No
9 empty 2.23 78.6 6.4 No No
10 empty 2.45 67.5 8.5 No No
5TOB_A Protein-tyrosine kinase 2-beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.74 73.4 33 Yes Yes
2 empty 1.98 67.1 29.4 No No
3 empty 2.4 62.3 28.2 No No
4 empty 2.34 62 27 No No
5 empty 2.18 61.9 18.9 No No
6 empty 2.06 65.5 11.5 No No
7 empty 1.57 63.1 12.1 No No
8 empty 1.92 65 19.8 No No
9 empty 2.09 69.9 12.5 No No
10 empty 2.43 58.6 11.5 No No
4EKU_A Protein-tyrosine kinase 2-beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 66.1 44 Yes Yes
2 empty 2.17 66.2 24.3 No No
3 empty 1.81 69.2 18.6 No No
4 empty 1.93 66.1 26.7 No No
5 empty 2.1 67.9 27.7 No No
6 empty 1.95 52.4 23.9 No No
7 empty 2.16 65.4 20.7 No No
8 empty 2.37 58.1 19 No No
9 empty 2.29 62.5 16.5 No No
10 empty 1.72 67.9 12.5 No No
3H3C_A Protein-tyrosine kinase 2-beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 70 41 Yes Yes
2 empty 2.47 59.8 27 No No
3 empty 2.32 66.3 17.8 No No
4 empty 2.54 67.5 21.5 No No
5 bound 2.16 63.3 19 No No
6 empty 1.95 63.7 14.6 No No
7 bound 1.5 63.3 15.6 No No
8 empty 2.37 71 11.9 No No
9 empty 2.09 63.3 10.1 No No
10 empty 2.02 47.5 8.8 No No
3GM1_A Protein-tyrosine kinase 2-beta No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 69 17.6 No No
2 empty 2.17 59.8 21.6 No No
3 empty 1.99 67.7 14.5 No No
4 empty 2.14 61.4 13.2 No No
5 empty 1.81 67.7 11.7 No No
6 empty 2.1 58.8 14.6 No No
7 empty 2.17 69.7 6.8 No No
8 empty 2.45 68.4 14 No No
9 empty 2.43 73.2 7.7 No No
10 empty 1.8 60.6 10.8 No No
4H1M_A Protein-tyrosine kinase 2-beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 73.6 38.1 Yes Yes
2 empty 2.25 67.3 24.8 No No
3 empty 2.29 63.4 22.3 No No
4 empty 2.13 64.4 19 No No
5 empty 1.66 66.1 17.1 No No
6 empty 2.1 61.9 15.9 No No
7 empty 2.3 61.7 23.2 No No
8 empty 2.16 65.9 16.8 No No
9 empty 2.6 64.1 15.6 No No
10 empty 2.44 57.1 10.8 No No
3FZT_A Protein-tyrosine kinase 2-beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.84 75.6 36.3 Yes Yes
2 empty 2.27 67.2 23.9 No No
3 empty 2.58 61.1 24.6 No No
4 empty 2.09 66.1 20.9 No No
5 empty 1.66 61.9 18.2 No No
6 empty 2.12 62.5 19 No No
7 empty 2.33 58.9 15 No No
8 empty 2.38 64.1 21 No No
9 empty 2.44 67.1 16.7 No No
10 empty 2.42 62.5 15.4 No No
4XEF_D Protein-tyrosine kinase 2-beta Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.32 60 24.1 Yes No
2 empty 2.15 63.7 15.2 No No
3 empty 1.72 60.3 16.6 No No
4 empty 1.62 72.1 11.3 No No
5 empty 2.2 60.1 8.8 No No
6 empty 2.2 72.8 9.6 No No
7 empty 1.69 75.9 6 No No
8 empty 2.6 64.1 7.7 No No
9 empty 2.16 63.2 8.1 No No
10 empty 1.97 67.1 7 No No
3CC6_A Protein-tyrosine kinase 2-beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.77 68.4 52.8 Yes Yes
2 empty 2.01 60.4 18.7 No No
3 empty 1.43 58.7 20.4 No No
4 empty 2.3 71.9 15 No No
5 empty 2.16 71.3 16.8 No No
6 empty 2.2 67.1 19.6 No No
7 empty 2.04 68.9 11.9 No No
8 empty 2.58 61.5 19.4 No No
9 empty 2.02 60.5 9.4 No No
10 empty 2.17 62.7 11.4 No No
4R32_A Protein-tyrosine kinase 2-beta No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 63.2 22 No No
2 empty 1.58 64.7 24.1 No No
3 empty 1.64 68.1 13.8 No No
4 empty 2.03 53.7 17.3 No No
5 empty 1.85 64.6 12.6 No No
6 empty 2.02 53.3 11.8 No No
7 empty 2.18 64.5 9.6 No No
8 empty 2.24 67.5 7.5 No No
9 empty 2.31 73.2 6.1 No No
10 empty 2.83 75.6 6.6 No No
3U3F_A Protein-tyrosine kinase 2-beta Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 61.1 25.3 Yes No
2 empty 1.9 71.3 12.4 No No
3 empty 1.66 67.8 12.1 No No
4 empty 2.26 60.8 13.4 No No
5 empty 2.56 68.5 10.7 No No
6 empty 2.32 75.7 9.1 No No
7 empty 1.68 68.9 10.8 No No
8 empty 1.93 61.8 9.9 No No
9 empty 2.54 62.4 10.5 No No
10 empty 1.83 55.9 8.6 No No
3FZS_A Protein-tyrosine kinase 2-beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 71.3 38.1 Yes Yes
2 empty 2.3 60.2 22.2 No No
3 empty 2.18 62.2 19.6 No No
4 empty 1.95 63.1 15.6 No No
5 empty 1.69 63.5 17.3 No No
6 empty 2.39 65.7 18.6 No No
7 empty 2.39 62.4 16.6 No No
8 empty 2.41 60.7 15.9 No No
9 empty 1.97 76.6 13.2 No No
10 empty 2.52 53.6 10.4 No No
4H1J_A Protein-tyrosine kinase 2-beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.57 74.2 44.2 Yes Yes
2 empty 2.48 61.7 31.2 No No
3 empty 2.24 67.4 24.9 No No
4 empty 2.25 63.7 20.7 No No
5 empty 2.1 63.1 15.4 No No
6 empty 2.48 60.6 25.2 No No
7 empty 1.8 59.4 19.6 No No
8 empty 2.35 64.7 16.6 No No
9 empty 1.99 76.5 14.3 No No
10 empty 2.76 69.9 7.7 No No
4XEK_A Protein-tyrosine kinase 2-beta Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.23 60.3 30.8 Yes No
2 empty 2.32 58.5 15.1 No No
3 empty 1.94 64.8 16.9 No No
4 empty 2.06 57.1 13.2 No No
5 empty 2.33 67 13.4 No No
6 empty 1.29 69.3 11 No No
7 empty 2.09 73.3 7.3 No No
8 empty 2.31 55.1 10.4 No No
9 empty 1.89 75.3 6.3 No No
10 empty 1.93 66 8.4 No No
3ET7_A Protein-tyrosine kinase 2-beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 69.4 44.1 Yes Yes
2 empty 2.33 70.8 22.3 No No
3 empty 1.36 64.2 20.9 No No
4 empty 1.96 61.8 17.6 No No
5 empty 2.1 62.4 16.8 No No
6 empty 1.94 63.7 14.3 No No
7 empty 2.48 56.3 14.7 No No
8 empty 2.39 60.6 13.7 No No
9 empty 2.28 58.1 19.9 No No
10 empty 2.43 59 11.7 No No
4XEF_A Protein-tyrosine kinase 2-beta Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 61.9 25.8 Yes No
2 empty 2.17 54.7 19.1 No No
3 empty 1.77 69 10.8 No No
4 empty 1.86 67.6 9 No No
5 empty 2.09 70.6 8.5 No No
6 empty 2.38 70.6 9.7 No No
7 empty 2.16 57.6 9.6 No No
8 empty 2.5 54.8 9.3 No No
9 empty 1.96 76.3 6.3 No No
10 empty 1.89 64.9 7.9 No No
3U3F_B Protein-tyrosine kinase 2-beta No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 61.6 22.3 No No
2 empty 2.22 61.3 18.7 No No
3 empty 2.04 61.1 18 No No
4 empty 1.56 76.5 13.6 No No
5 empty 1.77 63.3 13.6 No No
6 empty 1.83 68.8 9.5 No No
7 empty 2.49 68.1 7.9 No No
8 empty 1.99 71.5 7.6 No No
9 empty 1.78 70 9.4 No No
10 empty 2.57 64.8 8.1 No No
3GM3_A Protein-tyrosine kinase 2-beta Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.41 59.5 25 Yes No
2 empty 2.09 64.8 18.6 No No
3 empty 1.87 70.8 12.2 No No
4 empty 2.34 65.3 11.5 No No
5 empty 1.95 62.9 11.2 No No
6 empty 1.8 64.1 11.2 No No
7 empty 2 70.8 14.8 No No
8 empty 1.43 61.8 11.2 No No
9 empty 2.12 52.4 9.9 No No
10 empty 2.4 80.3 7.6 No No
3FZP_A Protein-tyrosine kinase 2-beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 72.5 39.4 Yes Yes
2 empty 2.29 56.6 29.1 No No
3 empty 2.16 65.7 16.8 No No
4 empty 2.31 60.8 28.7 No No
5 empty 2.61 64.9 20.9 No No
6 empty 2.24 57.1 19.4 No No
7 bound 2.15 67.7 19.6 No No
8 empty 2.45 60.7 18.9 No No
9 empty 1.43 65.9 13.7 No No
10 empty 1.84 66.7 9.1 No No
4XEV_A Protein-tyrosine kinase 2-beta No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 62.3 18.8 No No
2 empty 2.04 66.1 19.2 No No
3 empty 2.25 75.5 14.5 No No
4 empty 1.97 62.3 18.2 No No
5 empty 2.13 70.7 11.9 No No
6 empty 2.21 71.5 8.9 No No
7 empty 2.2 68.5 9.5 No No
8 empty 1.94 61.5 7.6 No No
9 empty 1.73 75 6.6 No No
10 empty 2.07 67.5 9.9 No No
3FZR_A Protein-tyrosine kinase 2-beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.64 70.4 41.4 Yes Yes
2 empty 2.11 70.1 22.2 No No
3 empty 2.2 60.8 20.6 No No
4 empty 1.31 61.8 19.7 No No
5 empty 1.88 68.6 16 No No
6 empty 2.42 58.7 21 No No
7 empty 2.02 60.6 19.6 No No
8 empty 2.12 57.4 14.8 No No
9 empty 2.4 72.8 8.2 No No
10 empty 2.26 69.9 12.3 No No
3FZO_A Protein-tyrosine kinase 2-beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.86 70.2 50 Yes Yes
2 empty 2.08 66.8 27.6 No No
3 empty 1.97 59.8 18.8 No No
4 empty 2.42 62.2 24 No No
5 empty 1.56 64.4 21.3 No No
6 empty 1.74 68.2 12.8 No No
7 empty 1.98 75.6 8.5 No No
8 empty 1.96 61 9.2 No No
9 empty 2.32 63.7 10.8 No No
10 empty 2.42 78.3 12.1 No No
2LK4_A Protein-tyrosine kinase 2-beta Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.32 52.3 25.4 Yes No
2 empty 2.31 56.8 24.8 No No
3 empty 2.23 65.1 14.3 No No
4 empty 2.06 49.1 13.5 No No
5 empty 2.32 66.3 11.9 No No
6 empty 2.4 64.3 13.2 No No
7 empty 2.25 60.8 11.9 No No
8 empty 2.24 76.6 10.3 No No
9 empty 2.34 63.8 9.3 No No
10 empty 2.37 58.2 9.9 No No
3GM1_B Protein-tyrosine kinase 2-beta Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 65.9 24 Yes No
2 empty 2.27 71.4 13.3 No No
3 empty 1.69 69.4 16.8 No No
4 empty 2.03 64.7 10.8 No No
5 empty 2.07 66.1 12.8 No No
6 empty 2.75 72.6 6.9 No No
7 empty 2.4 69.2 9.3 No No
8 empty 2.19 69.7 9.7 No No
9 empty 1.99 70.9 6.8 No No
10 empty 2.75 68.6 8.2 No No
3U3F_D Protein-tyrosine kinase 2-beta No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.56 55.2 16.7 No No
2 empty 1.57 69.9 11 No No
3 empty 2.14 59.3 14.9 No No
4 empty 2.09 64 9.9 No No
5 empty 2.2 66.4 12.7 No No
6 empty 1.8 69.4 11.2 No No
7 empty 2.41 72.3 7.2 No No
8 empty 2.16 61.4 9.7 No No
9 empty 1.47 79.9 10 No No
10 empty 2.16 52.1 8.8 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed11
Domains assessed as druggable using the strict criteria8
Domains assessed as druggable using the relaxed criteria9

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
3CC6_A (3330752) Protein-tyrosine kinase 2-beta Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 1.6Å Yes Yes
3ET7_A (3390363) Protein-tyrosine kinase 2-beta Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.7Å Yes Yes
3FZO_A (3420318) Protein-tyrosine kinase 2-beta Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.2Å Yes Yes
3FZP_A (3420320) Protein-tyrosine kinase 2-beta Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.1Å Yes Yes
3FZR_A (3420322) Protein-tyrosine kinase 2-beta Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2.7Å Yes Yes
3FZS_A (3420323) Protein-tyrosine kinase 2-beta Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 1.75Å Yes Yes
3FZT_A (3420324) Protein-tyrosine kinase 2-beta Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 1.95Å Yes Yes
3GM1_A (3430834) Protein-tyrosine kinase 2-beta Four-helical up-and-down bundle, FAT domain of focal adhesion kinase, UNMATCHED 2.95Å No No
3GM2_A (3430837) Protein-tyrosine kinase 2-beta Four-helical up-and-down bundle, FAT domain of focal adhesion kinase, UNMATCHED 2.7Å No No
3GM3_A (3430839) Protein-tyrosine kinase 2-beta Four-helical up-and-down bundle, FAT domain of focal adhesion kinase, UNMATCHED 2.6Å Yes No
3H3C_A (3450104) Protein-tyrosine kinase 2-beta Protein kinase-like (PK-like), Protein kinase-like (PK-like), Protein kinases catalytic subunit 2Å Yes Yes
Ligand-based Druggability Score: 0.9
Ligand-based Druggability Score Percentile: 89%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


PTK2B is involved in 74 interactions in the network.


Druggability
Overall Druggability Percentile: 98.61
Druggability for Cancer Therapeutics: 98.82
Druggability for Other Therapeutics: 98.31
Cancer-Associated
Cancer-associated percentile : 97.94
Network Articulation Point
Is PTK2B critical for communication in the network?


Detailed Graph Legend:Help