Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CRMP1 (Q14194) - Overview - Molecular Target Synopsis

Protein


CRMP1, Dihydropyrimidinase-related protein 1
UniProt Q14194

Also Known as DPYL1_HUMAN, CRMP1, DPYSL1, ULIP3

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis. Homotetramer, and heterotetramer with DPYSL2, DPYSL3, DPYSL4 or DPYSL5. Interacts with PLXNA1.

4B3Z
STRUCTURE OF THE HUMAN COLLAPSIN RESPONSE MEDIATOR PROTEIN-1, A LUNG CANCER SUPPRESSOR
RCSB/PDB
Inspect Structure
See all 3D Structures for CRMP1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CRMP1 is active in the following subcellular-locations: centrosome, cytoplasm, cytoskeleton, microtubule organizing center, spindle.
GO terms: CRMP1 is active in the following subcellular-locations: centrosome, cytosol, midbody, nucleus, spindle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CRMP1 has gain in 1 cell-lines, loss in 5 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H522, HOP_62, SW_620

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-N-FI, NCI-H187, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, IMR-90

(see details)

3D Structures


For CRMP1 there are:
1 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CRMP1 has been screened with compounds ( bioactivities). (see details)