Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB33A (Q14088) - Overview - Molecular Target Synopsis

Protein


RAB33A, Ras-related protein Rab-33A
UniProt Q14088

Also Known as RB33A_HUMAN, RAB33A, RABS10

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
237ENSG00000134594ENST00000257017ENSP00000257017Q14088-1

Sub-cellular localization


UniProt: RAB33A is active in the following subcellular-locations: cell membrane.
GO terms: RAB33A is active in the following subcellular-locations: endoplasmic reticulum membrane, Golgi membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB33A has gain in 0 cell-lines, loss in 26 cell-lines and no signal in 979 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SR, MOLT_4, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OCI-LY-3, MeWo, A3/KAW

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, HMEC

(see details)

3D Structures


At greater than 50% identity similarity to RAB33A there are:
4 structures (4 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB33A has been screened with compounds ( bioactivities). (see details)