Molecular Target Synopsis
Overview
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Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

CAMK1 (Q14012) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/04/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 23/04/2019)


Chains assessed6
Chains with at least one site assessed as druggable using the strict criteria6
Chains with at least one site assessed as druggable using the relaxed criteria6


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4FG8_A Calcium/calmodulin-dependent protein kinase type 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.24 67.3 54.7 Yes Yes
2 empty 2.41 69.4 17.3 No No
3 empty 2.37 59.5 16.8 No No
4 empty 1.98 64.7 16.1 No No
5 empty 2.25 62.3 15.4 No No
6 empty 2.55 73.8 8.6 No No
7 empty 2.15 73.7 7 No No
8 empty 1.93 53.2 10.6 No No
9 empty 2.33 76 7.3 No No
10 empty 2.59 61.9 12.8 No No
4FG7_A Calcium/calmodulin-dependent protein kinase type 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.87 68.4 34.7 Yes Yes
2 empty 2.48 65.6 31.6 No No
3 empty 2.33 59.4 35.7 No No
4 empty 2.38 60 27.7 No No
5 empty 1.56 68.4 16.2 No No
6 empty 1.99 62.8 18 No No
7 empty 2.32 62 17.2 No No
8 empty 2.14 63.4 14 No No
9 empty 2.22 62.9 14.1 No No
10 empty 2.04 54.2 14.7 No No
4FG9_A Calcium/calmodulin-dependent protein kinase type 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 66.7 48.7 Yes Yes
2 empty 1.99 69.4 30.3 No No
3 empty 2.23 74.1 20.7 No No
4 empty 2.62 67.6 16.3 No No
5 empty 2.26 62.6 16.7 No No
6 empty 2.04 67.6 16.9 No No
7 empty 2.32 62.7 12.6 No No
8 empty 2.22 60.8 16.6 No No
9 empty 2.44 76.2 8.3 No No
10 empty 2.6 60.5 8.8 No No
4FGB_A Calcium/calmodulin-dependent protein kinase type 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.93 70 39 Yes Yes
2 empty 2.41 68.2 25.7 No No
3 empty 2.31 64.7 32.4 No No
4 empty 2.45 64.5 21.6 No No
5 empty 2.11 69.3 14.2 No No
6 empty 1.8 65 16.7 No No
7 empty 2.58 63.9 14.4 No No
8 empty 2.2 63.2 21.5 No No
9 empty 2.13 65.1 14.4 No No
10 empty 2.29 69.2 12.8 No No
4FG9_B Calcium/calmodulin-dependent protein kinase type 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.88 68.4 50 Yes Yes
2 empty 2.32 74.4 22 No No
3 empty 2.39 60.2 18 No No
4 empty 2.45 69.3 15.3 No No
5 empty 1.82 61.4 16.8 No No
6 empty 2.45 61.9 12.6 No No
7 empty 1.79 60.7 10.5 No No
8 empty 2.23 66.5 13.3 No No
9 empty 2.03 67.9 11.2 No No
10 empty 1.31 58.8 11.2 No No
4FG8_B Calcium/calmodulin-dependent protein kinase type 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 68.5 47.3 Yes Yes
2 empty 2.22 72.3 20.2 No No
3 empty 2.05 64.9 22.4 No No
4 empty 2.15 64.5 16.8 No No
5 empty 2.4 58 16.3 No No
6 empty 2.36 71.3 13.8 No No
7 empty 2.14 65.4 18.2 No No
8 empty 2.42 63 14 No No
9 empty 2.22 64.6 12.7 No No
10 empty 2.36 59.1 8.9 No No
Ligand-based Druggability Score: -0.6
Ligand-based Druggability Score Percentile: 73%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


CAMK1 is involved in 19 interactions in the network.


Druggability
Overall Druggability Percentile: 90.06
Druggability for Cancer Therapeutics: 84.36
Druggability for Other Therapeutics: 84.83
Cancer-Associated
Cancer-associated percentile : 78.21
Network Articulation Point
Is CAMK1 critical for communication in the network?


Detailed Graph Legend:Help