Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARFRP1 (Q13795) - Overview - Molecular Target Synopsis

Protein


ARFRP1, ADP-ribosylation factor-related protein 1
UniProt Q13795

Also Known as ARFRP_HUMAN, ARFRP1, ARP1

Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. Interacts with SYS1.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ARFRP1 is active in the following subcellular-locations: golgi apparatus, trans-golgi network.
GO terms: ARFRP1 is active in the following subcellular-locations: cytosol, Golgi apparatus, membrane, trans-Golgi network, trans-Golgi network membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ARFRP1 has gain in 7 cell-lines, loss in 1 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MOLT_4, CAKI_1, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: PK-45P, HCC1171, HCC4017

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, A549

(see details)

3D Structures


At greater than 35% identity similarity to ARFRP1 there are:
23 structures (34 chains) solved
23 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis