Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB32 (Q13637) - Overview - Molecular Target Synopsis

Protein


RAB32, Ras-related protein Rab-32
UniProt Q13637

Also Known as RAB32_HUMAN, RAB32

Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission (PubMed:12186851). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. Interacts with ANKRD27 (PubMed:24856514, PubMed:21269460). A decreased interaction with ANKRD27 seen in the presence of SGSM2 (PubMed:21269460).

6FF8
CRYSTAL STRUCTURE OF UNCOMPLEXED RAB32 IN THE ACTIVE GTP-BOUND STATE AT 2.13 ANGSTROM RESOLUTION
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB32

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
225ENSG00000118508ENST00000367495ENSP00000356465Q13637-1

Sub-cellular localization


UniProt: RAB32 is active in the following subcellular-locations: cytoplasmic vesicle, melanosome, melanosome membrane, mitochondrion, mitochondrion outer membrane, phagosome, phagosome membrane.
GO terms: RAB32 is active in the following subcellular-locations: cytosol, early endosome, endoplasmic reticulum, melanosome, melanosome membrane, membrane, mitochondria-associated endoplasmic reticulum membrane, mitochondrial outer membrane, mitochondrion, phagocytic vesicle, phagocytic vesicle membrane, trans-Golgi network.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB32 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: BT_549, SK_MEL_28, NCI_H226

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-MEL-28, HCC193, 537 MEL

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, BJ, HSMM

(see details)

3D Structures


For RAB32 there are:
5 structures (10 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis