Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB31 (Q13636) - Overview - Molecular Target Synopsis

Protein


RAB31, Ras-related protein Rab-31
UniProt Q13636

Also Known as RAB31_HUMAN, RAB31, RAB22B

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Interacts with OCRL. Interacts with NGFR (By similarity). Interacts (in GDP-bound form) with RIN3 and GAPVD1, which function as guanine exchange factors (GEF). Interacts (in GTP-bound form) with EEA1. Interacts with EGFR. Interacts (in GTP-bound form) with APPL2; interaction contributes to or enhances recruitment of APPL2 to the phagosomes; interaction enhances Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages.

2FG5
CRYSTAL STRUCTURE OF HUMAN RAB31 IN COMPLEX WITH A GTP ANALOGUE
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB31

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB31 is active in the following subcellular-locations: cytoplasmic vesicle, early endosome, golgi apparatus, phagosome, phagosome membrane, trans-golgi network, trans-golgi network membrane.
GO terms: RAB31 is active in the following subcellular-locations: cytosol, early endosome, early endosome membrane, early phagosome membrane, phagocytic cup, phagocytic vesicle, plasma membrane, secretory granule membrane, trans-Golgi network membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB31 has gain in 5 cell-lines, loss in 5 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HOP_62, HOP_92, SF_295

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H2795, GR-M, G111

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, NHLF, NHEK

(see details)

3D Structures


For RAB31 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB31 has been screened with compounds ( bioactivities). (see details)