Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TSTA3 (Q13630) - Overview - Molecular Target Synopsis

Protein


TSTA3, GDP-L-fucose synthase
Enzyme Classification 1.1.1.271
UniProt Q13630

Also Known as FCL_HUMAN, TSTA3, SDR4E1

Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. Homodimer.

4BL5
CRYSTAL STRUCTURE OF HUMAN GDP-L-FUCOSE SYNTHASE WITH BOUND NADP AND PRODUCT GDP-L-FUCOSE
RCSB/PDB
Inspect Structure
See all 3D Structures for TSTA3

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: TSTA3 is active in the following subcellular-locations: cytosol, extracellular exosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TSTA3 has gain in 9 cell-lines, loss in 2 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_ADR_RES, OVCAR_4, NCI_H322M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DV-90, MDA-MB-436, NCI-H1781

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HMEC, A549

(see details)

3D Structures


For TSTA3 there are:
5 structures (26 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis