DYRK1A (Q13627) - Overview - Molecular Target Synopsis
DYRK1A, Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Enzyme Classification 18.104.22.168
Also Known as DYR1A_HUMAN, DYRK1A, DYRK, MNB, MNBH
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis. Interacts RAD54L2/ARIP4 (By similarity). Interacts with CRY2 (By similarity). Interacts with RANBP9 (PubMed:14500717). Interacts with WDR68 (PubMed:14593110). Interacts with SRSF6 (PubMed:22767602). Interacts with SIRT1.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|584||ENSG00000157540||ENST00000451934, ENST00000338785||ENSP00000416089, ENSP00000342690||Q13627-5|
UniProt: DYRK1A is active in the following subcellular-locations: nucleus, nucleus speckle.
GO terms: DYRK1A is active in the following subcellular-locations: axon, cytoplasm, cytoskeleton, dendrite, nuclear speck, nucleoplasm, nucleus, ribonucleoprotein complex.