Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC12A1 (Q13621) - Overview - Molecular Target Synopsis

Protein


SLC12A1, Solute carrier family 12 member 1
UniProt Q13621

Also Known as S12A1_HUMAN, SLC12A1, NKCC2

Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.

Isoforms / Transcripts (Protein Coding)


Drugs


SLC12A1 is targeted by Approved Drugs Furosemide, Ethacrynic Acid, Torsemide, Bumetanide. (see details)
Furosemide
Ethacrynic Acid
Torsemide
Bumetanide

Sub-cellular localization


UniProt: SLC12A1 is active in the following subcellular-locations: membrane.
GO terms: SLC12A1 is active in the following subcellular-locations: apical plasma membrane, extracellular exosome, integral component of membrane, membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC12A1 has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, HL_60, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: YMB-1, Hs 746T, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)


Screening and Chemistry


SLC12A1 has been screened with compounds ( bioactivities). (see details)