Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CAMK2G (Q13555) - Overview - Molecular Target Synopsis

Protein


CAMK2G, Calcium/calmodulin-dependent protein kinase type II subunit gamma
Enzyme Classification 2.7.11.17
UniProt Q13555

Also Known as KCC2G_HUMAN, CAMK2G, CAMK, CAMK-II, CAMKG

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other.

2V7O
CRYSTAL STRUCTURE OF HUMAN CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE II GAMMA
RCSB/PDB
Inspect Structure
See all 3D Structures for CAMK2G

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CAMK2G is active in the following subcellular-locations: sarcoplasmic reticulum membrane.
GO terms: CAMK2G is active in the following subcellular-locations: cytoplasm, cytosol, endocytic vesicle membrane, membrane, neuron projection, nucleoplasm, plasma membrane, sarcoplasmic reticulum membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CAMK2G has gain in 5 cell-lines, loss in 1 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: PC_3, HT29, NCI_ADR_RES

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MFM-223, PC-3, NCI-H1915

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, HSMM

(see details)

RNA Interference


CAMK2G was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: OVTOKO, MIAPACA2. (see details)

3D Structures


For CAMK2G there are:
2 structures (7 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CAMK2G has been screened with 526 compounds (857 bioactivities), 30 compounds have bioactivities that show binding affinity of <= 500nM (40 bioactivities). (see details)