CAMK2G (Q13555) - Overview - Molecular Target Synopsis
CAMK2G, Calcium/calmodulin-dependent protein kinase type II subunit gamma
Enzyme Classification 22.214.171.124
Also Known as KCC2G_HUMAN, CAMK2G, CAMK, CAMK-II, CAMKG
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|495||ENSG00000148660||ENST00000351293||ENSP00000277853||Q13555-10, Q923T9-3, P11730-3|
UniProt: CAMK2G is active in the following subcellular-locations: sarcoplasmic reticulum membrane.
GO terms: CAMK2G is active in the following subcellular-locations: cytoplasm, cytosol, endocytic vesicle membrane, membrane, neuron projection, nucleoplasm, plasma membrane, sarcoplasmic reticulum membrane.