Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PRPF4B (Q13523) - Overview - Molecular Target Synopsis

Protein


PRPF4B, Serine/threonine-protein kinase PRP4 homolog
Enzyme Classification 2.7.11.1
UniProt Q13523

Also Known as PRP4B_HUMAN, PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K

Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF. Identified in the spliceosome C complex. Interacts with Clk1 C-terminus.

6CNH
HUMAN PRPF4B IN COMPLEX WITH REBASTINIB
RCSB/PDB
Inspect Structure
See all 3D Structures for PRPF4B

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PRPF4B is active in the following subcellular-locations: nucleus.
GO terms: PRPF4B is active in the following subcellular-locations: catalytic step 2 spliceosome, chromosome, nuclear speck, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PRPF4B has gain in 3 cell-lines, loss in 2 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SR, HL_60, MDA_MB_231

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1882, SNU-398, CPC-N

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, NHLF

(see details)

3D Structures


For PRPF4B there are:
5 structures (9 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PRPF4B has been screened with 74 compounds (74 bioactivities), 7 compounds have bioactivities that show binding affinity of <= 500nM (7 bioactivities). (see details)