Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MAMLD1 (Q13495) - Overview - Molecular Target Synopsis

Protein


MAMLD1, Mastermind-like domain-containing protein 1
UniProt Q13495

Also Known as MAMD1_HUMAN, MAMLD1, CG1, CXorf6

Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MAMLD1 is active in the following subcellular-locations: nucleus.
GO terms: MAMLD1 is active in the following subcellular-locations: centrosome, Golgi apparatus, nuclear body, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MAMLD1 has gain in 0 cell-lines, loss in 25 cell-lines and no signal in 980 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MDA_MB_231, HOP_92, BT_549

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COV434, NCI-H1915, HCC461

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, IMR-90

(see details)