Molecular Target Synopsis
Overview
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RNAi
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BIRC2 (Q13490) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed39
Chains with at least one site assessed as druggable using the strict criteria1
Chains with at least one site assessed as druggable using the relaxed criteria35


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4LGE_A Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.37 65.2 27.2 Yes No
2 empty 2.12 60.6 14.3 No No
3 empty 2.19 57.8 13.8 No No
4 empty 2.03 57.8 16.5 No No
5 empty 2.29 65.9 11.1 No No
6 empty 2.14 54.3 10.2 No No
7 empty 1.63 63.8 10 No No
8 empty 2.65 66.7 7 No No
9 empty 2.56 73.8 8.1 No No
10 empty 2.44 60.2 7.6 No No
6EXW_A Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 62.8 32.3 Yes No
2 empty 2.48 61.4 23.2 No No
3 empty 2.37 62.8 17.4 No No
4 empty 1.95 56.9 9.3 No No
5 empty 2.1 57.1 10.6 No No
6 empty 2.39 67.1 7.5 No No
7 empty 2.61 67.1 6.5 No No
8 empty 2.03 50.4 6.9 No No
9 empty 2.78 72.8 5 No No
10 empty 3.53 72.5 5.9 No No
4MU7_A Baculoviral IAP repeat-containing protein 2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.29 62 22.1 No No
2 empty 2.58 62.8 11.4 No No
3 empty 2.26 66.8 12.2 No No
4 empty 2.48 62.2 11.3 No No
5 empty 2.14 52.5 13 No No
6 empty 1.44 63.4 8.7 No No
7 empty 2.04 65.7 7.4 No No
8 empty 2.08 52.8 9.9 No No
9 empty 1.82 59.8 7.1 No No
10 empty 2.29 66.9 8.4 No No
3M1D_A Baculoviral IAP repeat-containing protein 2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 63.8 21.5 No No
2 empty 2.46 63.2 11.4 No No
3 empty 2.2 61.8 11.4 No No
4 empty 2.48 64.8 10 No No
5 empty 2.68 62.9 10.8 No No
6 empty 2.37 59.9 7.7 No No
7 empty 2.44 75.5 5.3 No No
8 empty 3.28 55.6 6.7 No No
9 empty 2.07 64.4 7.2 No No
10 empty 2.41 63.4 6.3 No No
6HPR_A Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 59.5 24.8 Yes No
2 empty 2.18 69.6 10.8 No No
3 empty 2.55 55.9 16.5 No No
4 empty 2.53 60.3 8.4 No No
5 empty 1.59 54.1 7.5 No No
6 empty 2.17 72 0 No No
7 empty 2.03 64.2 0 No No
3MUP_B Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.18 60.8 38.1 Yes No
2 empty 2.19 66.2 9.1 No No
3 empty 2.55 62.4 12.2 No No
4 empty 1.86 56.7 6.8 No No
5 empty 2.11 59 7.7 No No
6 empty 2.33 64.7 8.4 No No
7 empty 2 49.1 8.2 No No
8 empty 2.68 69 5.7 No No
9 empty 2.32 64.5 5.2 No No
10 empty 2.08 56.2 5.6 No No
4EB9_D Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.1 58.2 28.9 Yes No
2 empty 2.52 60.5 28 No No
3 empty 1.95 60.9 14.3 No No
4 empty 2.21 57.7 12 No No
5 empty 2.02 58.9 10.3 No No
6 empty 2.56 74.9 11.3 No No
7 empty 2.96 71.9 5.7 No No
8 empty 2.96 72.7 7.4 No No
9 empty 1.84 61 5.5 No No
10 empty 3.78 62.6 6.1 No No
3OZ1_D Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.29 59.5 28.2 Yes No
2 empty 1.91 63.3 16 No No
3 empty 1.97 58.2 14.2 No No
4 empty 2.33 65.5 11.3 No No
5 empty 2.11 61.5 11 No No
6 empty 2.43 62.9 9 No No
7 empty 2.32 59.6 7.9 No No
8 empty 2.76 68.6 7.4 No No
9 empty 1.65 65.6 7.3 No No
10 empty 2.68 62.3 5.7 No No
3OZ1_B Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.21 62.3 27.1 Yes No
2 empty 2.29 57.6 17.4 No No
3 empty 2.11 64.7 19.3 No No
4 empty 2.01 59.1 16.4 No No
5 empty 2.13 56.4 11.2 No No
6 empty 2.59 70.9 8.5 No No
7 empty 1.9 43.9 8.6 No No
8 empty 2.67 66.7 6.9 No No
9 empty 2.46 50.4 8.3 No No
10 empty 2.1 57.6 7.8 No No
4HY5_B Baculoviral IAP repeat-containing protein 2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.33 63.5 20.2 No No
2 empty 2.25 57.7 20.9 No No
3 empty 2.17 57.5 14 No No
4 empty 2.45 58.7 9.7 No No
5 empty 2.16 57.7 15 No No
6 empty 2.71 59 8.9 No No
7 empty 2.86 59.7 7.8 No No
8 empty 1.81 58.3 6.6 No No
9 empty 1.89 48.1 7.8 No No
10 empty 1.73 59.8 6.9 No No
5M6N_A Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.27 64.4 24.8 Yes No
2 empty 2.04 55.6 18.9 No No
3 empty 2.11 60.9 19.7 No No
4 empty 2.35 61.4 11.2 No No
5 empty 2.85 63.7 10.5 No No
6 empty 2 60.6 7.9 No No
7 bound 2.57 63.1 10.1 No No
8 empty 2.09 53.3 11.1 No No
9 empty 2.26 59.2 8 No No
10 empty 1.83 47.5 7.8 No No
6EXW_C Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.48 63.5 26.2 Yes No
2 empty 2.45 62 27 No No
3 empty 2.32 60.7 17 No No
4 empty 2.48 60.6 15.9 No No
5 empty 2.4 52.6 9.8 No No
6 empty 2.86 72.7 9.2 No No
7 empty 2.16 57.7 9.2 No No
8 empty 2.28 60.6 8.4 No No
9 empty 2.26 53 7.9 No No
10 empty 2.57 71.7 5.1 No No
4MTI_B Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.28 63.1 24.5 Yes No
2 empty 2.43 60.6 16.8 No No
3 empty 2.23 60.5 14.2 No No
4 empty 2.28 54.6 11 No No
5 empty 2.12 54.5 14.3 No No
6 empty 1.87 55.6 11.5 No No
7 empty 1.44 65.3 9.8 No No
8 empty 2.23 62.8 9 No No
9 empty 2.04 61.1 9.1 No No
10 empty 2.55 66.4 9.4 No No
4EB9_A Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 61 32.4 Yes No
2 empty 2.29 67.2 14.5 No No
3 empty 2.21 67 14.3 No No
4 empty 2.06 56.7 12.6 No No
5 empty 2.09 62 9.1 No No
6 empty 1.97 50.4 7.8 No No
7 empty 2.7 74.4 6.3 No No
8 empty 1.76 58.2 6.1 No No
9 empty 2.43 50.4 7.5 No No
10 empty 2.98 63.6 7.7 No No
4LGU_B Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.57 63.7 27.6 Yes No
2 empty 2.28 64.2 15.8 No No
3 empty 2.33 59.2 13.7 No No
4 empty 1.73 54.8 14.2 No No
5 empty 2.11 54.7 8.9 No No
6 empty 2.11 58.3 9.5 No No
7 empty 2.19 60.8 9.9 No No
8 empty 2.53 68.1 7.3 No No
9 empty 2.29 58.6 11.3 No No
10 empty 2.64 70.4 7.1 No No
3UW4_A Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.43 63.8 31.5 Yes No
2 empty 2.24 59.5 13.8 No No
3 empty 2.12 61.4 7.1 No No
4 empty 2.07 58.2 9 No No
5 empty 2.84 55.8 8.6 No No
6 empty 2 57 7.8 No No
7 empty 2.91 65.7 6.9 No No
8 empty 1.48 66 7.6 No No
9 empty 2.68 63 6.5 No No
10 empty 3.58 74.3 6.4 No No
3D9U_A Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.55 62.4 27.4 Yes No
2 empty 2.41 61.9 15.3 No No
3 empty 2.02 60.7 14.5 No No
4 empty 2.34 66.9 13.6 No No
5 empty 2.23 55.6 13.2 No No
6 empty 2.41 63.5 15.5 No No
7 empty 3.05 67.4 6.8 No No
8 empty 2.7 67.2 6.3 No No
9 empty 2.78 80.2 6.2 No No
10 empty 1.93 69.6 5.5 No No
3M1D_B Baculoviral IAP repeat-containing protein 2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 65.3 13.9 No No
2 empty 2.17 72 13.8 No No
3 empty 2.23 53.9 8.8 No No
4 empty 2.3 65.7 12 No No
5 empty 2.8 57 9.7 No No
6 empty 2.04 69 7.6 No No
7 empty 2.35 64.7 7.7 No No
8 empty 2.99 55.2 6.6 No No
9 empty 2.77 57.8 7.9 No No
10 empty 2.69 62.2 6.9 No No
4HY4_B Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.54 64.2 26.9 Yes No
2 empty 2.2 61.8 18 No No
3 empty 2.49 53.1 11.4 No No
4 empty 2.6 62.9 8.5 No No
5 empty 2.66 60.7 12.2 No No
6 empty 1.82 57.4 15.2 No No
7 empty 2.62 68.2 6.6 No No
8 empty 2.43 65.2 8 No No
9 empty 2.29 57.4 7.8 No No
10 empty 2.31 55 8.8 No No
3MUP_C Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.11 58.9 27.7 Yes No
2 empty 2.23 63.6 13.5 No No
3 empty 2.11 56.6 15.7 No No
4 empty 2.22 64.6 9.8 No No
5 empty 2.86 66 7.4 No No
6 empty 2.17 51.3 9.5 No No
7 empty 2.55 60.2 9.9 No No
8 empty 1.83 53.6 9.8 No No
9 empty 2.01 48.7 8 No No
10 empty 2.69 66.9 7 No No
3T6P_A Baculoviral IAP repeat-containing protein 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.56 70.7 54.1 Yes Yes
2 empty 2.32 64.6 31.7 No No
3 empty 2.09 69 29.2 No No
4 empty 2.24 68.9 15.1 No No
5 empty 2.25 65.9 15.6 No No
6 empty 1.6 99.2 0 Yes No
7 empty 2.66 58.9 11 No No
8 empty 2.36 67.4 13 No No
9 empty 2.48 63.6 8.3 No No
10 empty 1.71 60.6 8.7 No No
3D9T_A Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 62.1 24.5 Yes No
2 empty 2.36 57.6 20.9 No No
3 empty 2.36 57.7 10.5 No No
4 empty 2.38 57 10.7 No No
5 empty 1.97 56.8 7.1 No No
6 empty 1.4 52.2 12.2 No No
7 empty 2 55.8 6.8 No No
8 empty 2.87 66.2 8 No No
9 empty 1.86 45.5 7 No No
10 empty 2.3 57.8 7.1 No No
5M6N_B Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.44 62.9 28.6 Yes No
2 empty 2.37 60.1 19.4 No No
3 empty 1.75 60.9 12.5 No No
4 empty 2.66 65.5 10.1 No No
5 empty 2.45 65.6 7.6 No No
6 empty 2.1 58.8 9.2 No No
7 empty 2.17 64.2 9.2 No No
8 empty 1.82 44.1 7.9 No No
9 empty 2.13 56 8 No No
10 empty 1.87 55.2 11 No No
4EB9_C Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.23 57.4 35 Yes No
2 empty 2.02 68.7 11.5 No No
3 empty 2.68 64.7 9.9 No No
4 empty 1.94 63.7 10.2 No No
5 empty 1.98 51.5 9.3 No No
6 empty 2.52 69.9 8.8 No No
7 empty 3.04 71.6 2.7 No No
8 empty 2.06 41.8 7.5 No No
9 empty 2.46 57 7.1 No No
10 empty 2.49 85.1 5.8 Yes No
3OZ1_C Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.32 59.7 33.5 Yes No
2 empty 2.36 69 17.6 No No
3 empty 2.15 58.1 15.4 No No
4 empty 2.15 55.2 9.6 No No
5 empty 1.95 59 11.8 No No
6 empty 3.02 62.8 8.5 No No
7 empty 2.25 51.2 10.7 No No
8 empty 2.32 68.2 6.5 No No
9 empty 2.11 54 8.6 No No
10 empty 1.19 48.9 7.4 No No
3MUP_A Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.2 61.2 27.6 Yes No
2 empty 2.26 63 16.4 No No
3 empty 2.26 62.1 13.8 No No
4 empty 2.33 63.9 15 No No
5 empty 1.9 64.1 11.3 No No
6 empty 2.1 63 7.4 No No
7 empty 2.23 53.9 9.1 No No
8 empty 2.73 69.8 5.5 No No
9 empty 2.13 44.2 7.3 No No
10 empty 2.46 51.2 7.3 No No
3OZ1_A Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.28 60.8 26 Yes No
2 empty 2.36 63.2 14.4 No No
3 empty 2.2 59.3 17.3 No No
4 empty 2.08 61.8 11 No No
5 empty 2.07 58.5 8.6 No No
6 empty 2.86 61.9 8.7 No No
7 empty 1.91 60.8 10.7 No No
8 empty 2.67 63.6 7.2 No No
9 empty 2.5 46 8.7 No No
10 empty 2.84 51.6 6.2 No No
4LGU_A Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.45 60.8 30 Yes No
2 empty 2.34 60.9 11.8 No No
3 empty 2.23 60.6 14.2 No No
4 empty 2.06 56 12.7 No No
5 empty 2.12 55.9 10.5 No No
6 empty 2.25 55.3 13.9 No No
7 empty 1.48 62.9 10 No No
8 empty 1.83 57.1 10.8 No No
9 empty 2.3 62 10.4 No No
10 empty 2.66 65.3 9 No No
2L9M_A Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 61.5 30 Yes No
2 empty 1.84 77.3 18.7 No No
3 empty 2.08 60.2 20.1 No No
4 empty 1.81 61.7 16.9 No No
5 empty 2.48 76.6 16.7 No No
6 empty 2.14 61 11.5 No No
7 empty 2.58 62.1 18.8 No No
8 empty 2.37 47.7 12.6 No No
9 empty 1.71 79.8 8 No No
10 empty 2.16 63.9 10.2 No No
3MUP_D Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.35 59 26.7 Yes No
2 empty 2.32 65.2 16.6 No No
3 empty 2.23 60.6 14 No No
4 empty 2.28 61.8 13.3 No No
5 empty 1.75 66.3 8.8 No No
6 empty 2.1 53.5 13.6 No No
7 empty 2.33 57.1 9.6 No No
8 empty 2.92 63.8 7.7 No No
9 empty 1.99 48.3 6.9 No No
10 empty 3.01 63.5 7.3 No No
4MTI_A Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.54 62.9 26.6 Yes No
2 empty 2.45 65.9 16 No No
3 empty 2.38 62.2 11.9 No No
4 empty 2.31 50.3 9.1 No No
5 empty 2.04 58.5 12.7 No No
6 empty 1.88 56 14.7 No No
7 empty 2.12 55.3 11.6 No No
8 empty 2.55 57.1 11.5 No No
9 empty 2.35 59.1 7.7 No No
10 empty 1.7 61.4 6.8 No No
4EB9_B Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.36 61.2 33.9 Yes No
2 empty 1.91 64.2 15.9 No No
3 empty 2.1 60.9 15.5 No No
4 empty 2.15 57.1 12.7 No No
5 empty 2.7 65.4 10 No No
6 empty 2.03 56.3 8.5 No No
7 empty 2.84 70.5 6.6 No No
8 empty 2.54 59.5 7.3 No No
9 empty 1.92 61.6 5.8 No No
10 empty 3.13 74.6 6.2 No No
3D9T_B Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.59 66 27.2 Yes No
2 empty 2.38 65.4 16 No No
3 empty 2.79 53.5 16.5 No No
4 empty 2.38 61.3 11.8 No No
5 empty 2.26 58.2 12.6 No No
6 empty 1.89 56.8 11.1 No No
7 empty 2.29 72.1 6.6 No No
8 empty 1.84 50 10.6 No No
9 empty 2.42 63.7 9.8 No No
10 empty 1.73 61.3 6.4 No No
4MU7_B Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.62 63 26.4 Yes No
2 empty 2.35 64.5 18.2 No No
3 empty 2.29 60.2 18.8 No No
4 empty 2 57.7 9.7 No No
5 empty 1.49 57.5 11.8 No No
6 empty 2.09 59.1 9 No No
7 empty 2.82 65.7 9.1 No No
8 empty 2.58 66.7 8 No No
9 empty 2.7 70.3 8.4 No No
10 empty 2.28 67.2 8 No No
4HY4_A Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.2 64.1 24.6 Yes No
2 empty 2.41 60.8 12.9 No No
3 empty 2.07 63.7 12.1 No No
4 empty 2.44 60.1 11.1 No No
5 empty 1.7 62.6 10.5 No No
6 empty 2.76 63.3 9.7 No No
7 empty 2.73 65.3 6.2 No No
8 empty 2.6 62.2 6.5 No No
9 empty 2.78 59.3 8.2 No No
10 empty 2.27 68.3 9 No No
1QBH_A Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 62.2 29.1 Yes No
2 empty 2.69 68.2 22.4 No No
3 empty 2.42 65 18.4 No No
4 empty 2.14 60.2 15.3 No No
5 empty 2.16 61.6 8.8 No No
6 empty 1.9 54.5 12.3 No No
7 empty 1.48 63.6 9.4 No No
8 empty 3.14 70.4 6.1 No No
9 empty 3.21 72.2 5.5 No No
10 empty 2.73 72.3 6.8 No No
4HY5_A Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.5 63.1 28.2 Yes No
2 empty 2.14 63.7 20.7 No No
3 empty 2.51 59.8 12.3 No No
4 empty 2.16 59 11.9 No No
5 empty 2.1 57.5 11.8 No No
6 empty 1.92 55.6 13.6 No No
7 empty 2.46 70.5 7.7 No No
8 empty 2.38 64.5 6.2 No No
9 empty 1.92 45.7 8.3 No No
10 empty 2.59 50.5 6.6 No No
4KMN_A Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.42 59.9 26.1 Yes No
2 empty 2.14 62.7 14.6 No No
3 empty 2.23 72.9 9.6 No No
4 empty 2.18 49.8 12.2 No No
5 empty 1.41 61.5 8.8 No No
6 empty 2.02 58.5 10 No No
7 empty 1.96 64.4 13.4 No No
8 empty 1.86 55.3 9.8 No No
9 empty 2.49 62.4 7.3 No No
10 empty 2.67 71.6 5 No No
4LGE_B Baculoviral IAP repeat-containing protein 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.42 65.8 26.4 Yes No
2 empty 2.3 58.6 20.9 No No
3 empty 2.28 56.9 16.7 No No
4 empty 2.59 59.2 12.8 No No
5 empty 2.29 62.1 11.7 No No
6 empty 2.13 59.8 7.6 No No
7 empty 2.67 70.6 6.8 No No
8 empty 2.47 68.9 7.8 No No
9 empty 2.51 65.8 7.3 No No
10 empty 2.24 51.8 9.5 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed10
Domains assessed as druggable using the strict criteria1
Domains assessed as druggable using the relaxed criteria9

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1QBH_A (45374) Baculoviral IAP repeat-containing protein 2 Inhibitor of apoptosis (IAP) repeat, Inhibitor of apoptosis (IAP) repeat, Inhibitor of apoptosis (IAP) repeat Yes No
2L9M_A (3580161) Baculoviral IAP repeat-containing protein 2 PFAM, PFAM, PFAM CARD Yes No
3D9T_A (157463) Baculoviral IAP repeat-containing protein 2 Inhibitor of apoptosis (IAP) repeat, Inhibitor of apoptosis (IAP) repeat, Inhibitor of apoptosis (IAP) repeat 1.5Å Yes No
3D9T_B (157464) Baculoviral IAP repeat-containing protein 2 Inhibitor of apoptosis (IAP) repeat, Inhibitor of apoptosis (IAP) repeat, Inhibitor of apoptosis (IAP) repeat 1.5Å Yes No
3D9U_A (157465) Baculoviral IAP repeat-containing protein 2 Inhibitor of apoptosis (IAP) repeat, Inhibitor of apoptosis (IAP) repeat, Inhibitor of apoptosis (IAP) repeat 2.3Å Yes No
3M1D_A (3540350) Baculoviral IAP repeat-containing protein 2 Inhibitor of apoptosis (IAP) repeat, Inhibitor of apoptosis (IAP) repeat, UNMATCHED 2Å No No
3MUP_A (4216250) Baculoviral IAP repeat-containing protein 2 Inhibitor of apoptosis (IAP) repeat, Inhibitor of apoptosis (IAP) repeat, Inhibitor of apoptosis (IAP) repeat (Homo Multimer) 2.6Å Yes No
3MUP_C (4216250) Baculoviral IAP repeat-containing protein 2 Inhibitor of apoptosis (IAP) repeat, Inhibitor of apoptosis (IAP) repeat, Inhibitor of apoptosis (IAP) repeat (Homo Multimer) 2.6Å Yes No
3MUP_A (3630554) Baculoviral IAP repeat-containing protein 2 Inhibitor of apoptosis (IAP) repeat, Inhibitor of apoptosis (IAP) repeat, UNMATCHED 2.6Å Yes No
3MUP_B (4216250) Baculoviral IAP repeat-containing protein 2 Inhibitor of apoptosis (IAP) repeat, Inhibitor of apoptosis (IAP) repeat, Inhibitor of apoptosis (IAP) repeat (Homo Multimer) 2.6Å Yes No
3MUP_D (4216250) Baculoviral IAP repeat-containing protein 2 Inhibitor of apoptosis (IAP) repeat, Inhibitor of apoptosis (IAP) repeat, Inhibitor of apoptosis (IAP) repeat (Homo Multimer) 2.6Å Yes No
3OZ1_A (3660110) Baculoviral IAP repeat-containing protein 2 Inhibitor of apoptosis (IAP) repeat, Inhibitor of apoptosis (IAP) repeat, UNMATCHED 3Å Yes No
3T6P_A (4260331) Baculoviral IAP repeat-containing protein 2 Inhibitor of apoptosis (IAP) repeat, Inhibitor of apoptosis (IAP) repeat, Inhibitor of apoptosis (IAP) repeat 1.897Å Yes Yes
Ligand-based Druggability Score: 0.65
Ligand-based Druggability Score Percentile: 86%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


BIRC2 is involved in 62 interactions in the network.


Druggability
Overall Druggability Percentile: 48.74
Druggability for Cancer Therapeutics: 91.24
Druggability for Other Therapeutics: 57.99
Cancer-Associated
Cancer-associated percentile : 85.36
Network Articulation Point
Is BIRC2 critical for communication in the network?


Detailed Graph Legend:Help