TNK1 (Q13470) - Overview - Molecular Target Synopsis
TNK1, Non-receptor tyrosine-protein kinase TNK1
Enzyme Classification 220.127.116.11
Also Known as TNK1_HUMAN, TNK1
Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. Interacts with the SH3 domain of PLCG1 via its Pro-rich domain.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|661||ENSG00000174292||ENST00000311668, ENST00000570896||ENSP00000312309, ENSP00000458834||Q13470-2|
UniProt: TNK1 is active in the following subcellular-locations: cytoplasm, membrane.
GO terms: TNK1 is active in the following subcellular-locations: cytoplasm, cytosol, membrane.