Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MSLN (Q13421) - Overview - Molecular Target Synopsis

Protein


MSLN, Mesothelin
UniProt Q13421

Also Known as MSLN_HUMAN, MSLN, MPF

Membrane-anchored forms may play a role in cellular adhesion., Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro. Interacts with MUC16.

4F3F
CRYSTAL STRUCTURE OF MSLN7-64 MORAB-009 FAB COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for MSLN

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MSLN is active in the following subcellular-locations: cell membrane, golgi apparatus, secreted.
GO terms: MSLN is active in the following subcellular-locations: anchored component of membrane, cell surface, endoplasmic reticulum lumen, extracellular region, extracellular space, Golgi apparatus, membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MSLN has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_ADR_RES, SN12C, HCC_2998

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Capan-2, OVKATE, COV644

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, SK-N-SH, NHLF

(see details)

3D Structures


For MSLN there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis