Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TARBP1 (Q13395) - Overview - Molecular Target Synopsis

Protein


TARBP1, Probable methyltransferase TARBP1
Enzyme Classification 2.1.1.-
UniProt Q13395

Also Known as TARB1_HUMAN, TARBP1, TRM3, TRP185

Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs., (Microbial infection) In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II (PubMed:7638159, PubMed:8626763, PubMed:8846792). Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA (PubMed:7638159, PubMed:8626763, PubMed:8846792). Monomer and homodimer.

2HA8
METHYLTRANSFERASE DOMAIN OF HUMAN TAR (HIV-1) RNA BINDING PROTEIN 1
RCSB/PDB
Inspect Structure
See all 3D Structures for TARBP1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1621ENSG00000059588ENST00000040877ENSP00000040877Q13395-1

Sub-cellular localization


GO terms: TARBP1 is active in the following subcellular-locations: nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TARBP1 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H522, MOLT_4, NCI_H460

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SUP-B15, OCI-AML2, SIG-M5

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, MCF-7

(see details)

3D Structures


For TARBP1 there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TARBP1 has been screened with compounds ( bioactivities). (see details)