TARBP1 (Q13395) - Overview - Molecular Target Synopsis
TARBP1, Probable methyltransferase TARBP1
Enzyme Classification 2.1.1.-
Also Known as TARB1_HUMAN, TARBP1, TRM3, TRP185
Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs., (Microbial infection) In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II (PubMed:7638159, PubMed:8626763, PubMed:8846792). Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA (PubMed:7638159, PubMed:8626763, PubMed:8846792). Monomer and homodimer.
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