Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PLD1 (Q13393) - Overview - Molecular Target Synopsis

Protein


PLD1, Phospholipase D1
Enzyme Classification 3.1.4.4
UniProt Q13393

Also Known as PLD1_HUMAN, PLD1

Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). Interacts with PIP5K1B.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PLD1 is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum membrane, golgi apparatus membrane, late endosome membrane, perinuclear region.
GO terms: PLD1 is active in the following subcellular-locations: apical plasma membrane, cholinergic synapse, endocytic vesicle, endoplasmic reticulum membrane, endosome, Golgi apparatus, Golgi membrane, late endosome membrane, lysosomal membrane, membrane, perinuclear region of cytoplasm, plasma membrane, specific granule membrane, tertiary granule membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PLD1 has gain in 14 cell-lines, loss in 0 cell-lines and no signal in 991 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, SK_MEL_28, HOP_92

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COR-L26, Hep G2, SCC-3

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: GM12878, HUVEC, HSMM

(see details)


Screening and Chemistry


PLD1 has been screened with 249 compounds (573 bioactivities), 149 compounds have bioactivities that show binding affinity of <= 500nM (300 bioactivities). (see details)