Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PTPRS (Q13332) - Overview - Molecular Target Synopsis

Protein


PTPRS, Receptor-type tyrosine-protein phosphatase S
Enzyme Classification 3.1.3.48
UniProt Q13332

Also Known as PTPRS_HUMAN, PTPRS

Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed:21454754). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PubMed:8524829). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (By similarity). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120). Binding to large heparan sulfate proteoglycan structures promotes oligomerization. Binding to chondroitin sulfate proteoglycan does not lead to oligomerization (By similarity). Interacts (via Ig-like domains) with NTRK3 (PubMed:25385546). Interacts (via Ig-like domains) with NTRK1, but does not form detectable complexes with NTRK2 (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3 (PubMed:8524829, PubMed:9624153).

4PBX
CRYSTAL STRUCTURE OF THE SIX N-TERMINAL DOMAINS OF HUMAN RECEPTOR PROTEIN TYROSINE PHOSPHATASE SIGMA
RCSB/PDB
Inspect Structure
See all 3D Structures for PTPRS

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PTPRS is active in the following subcellular-locations: axon, cell junction, cell membrane, cell projection, cytoplasmic vesicle, perikaryon, postsynaptic cell membrane, postsynaptic density, secretory vesicle, synapse, synaptic vesicle membrane, synaptosome.
GO terms: PTPRS is active in the following subcellular-locations: axon, cell junction, extracellular exosome, glutamatergic synapse, integral component of plasma membrane, integral component of postsynaptic density membrane, integral component of presynaptic membrane, integral component of synaptic vesicle membrane, perikaryon, plasma membrane, Schaffer collateral - CA1 synapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PTPRS has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: EKVX, SNB_75, BT_549

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H446, NCI-H2595, G-402

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, IMR-90

(see details)

3D Structures


For PTPRS there are:
6 structures (6 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PTPRS has been screened with 45 compounds (90 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)