PTPRS (Q13332) - Overview - Molecular Target Synopsis
PTPRS, Receptor-type tyrosine-protein phosphatase S
Enzyme Classification 18.104.22.168
Also Known as PTPRS_HUMAN, PTPRS
Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed:21454754). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PubMed:8524829). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (By similarity). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120). Binding to large heparan sulfate proteoglycan structures promotes oligomerization. Binding to chondroitin sulfate proteoglycan does not lead to oligomerization (By similarity). Interacts (via Ig-like domains) with NTRK3 (PubMed:25385546). Interacts (via Ig-like domains) with NTRK1, but does not form detectable complexes with NTRK2 (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3 (PubMed:8524829, PubMed:9624153).
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|1948||ENSG00000105426||ENST00000357368, ENST00000587303||ENSP00000349932, ENSP00000467537||Q13332-1|
|1910||ENSG00000105426||ENST00000348075, ENST00000588012||ENSP00000269907, ENSP00000465443||Q13332-6|
|1501||ENSG00000105426||ENST00000592099, ENST00000353284||ENSP00000467398, ENSP00000327313||Q13332-7|
UniProt: PTPRS is active in the following subcellular-locations: axon, cell junction, cell membrane, cell projection, cytoplasmic vesicle, perikaryon, postsynaptic cell membrane, postsynaptic density, secretory vesicle, synapse, synaptic vesicle membrane, synaptosome.
GO terms: PTPRS is active in the following subcellular-locations: axon, cell junction, extracellular exosome, glutamatergic synapse, integral component of plasma membrane, integral component of postsynaptic density membrane, integral component of presynaptic membrane, integral component of synaptic vesicle membrane, perikaryon, plasma membrane, Schaffer collateral - CA1 synapse.