Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PTK7 (Q13308) - Overview - Molecular Target Synopsis

Protein


PTK7, Inactive tyrosine-protein kinase 7
UniProt Q13308

Also Known as PTK7_HUMAN, PTK7, CCK4

Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. Interacts with CTNNB1.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PTK7 is active in the following subcellular-locations: cell junction, membrane.
GO terms: PTK7 is active in the following subcellular-locations: cell-cell junction, focal adhesion, integral component of plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PTK7 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SF_539, SK_OV_3, HCT_15

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SCC-9, A-431, OUMS-23

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, BJ, HMEC

(see details)

RNA Interference


PTK7 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: PL5, CAOV3. (see details)

3D Structures


At greater than 35% identity similarity to PTK7 there are:
154 structures (226 chains) solved
130 are solved in complex with at least one small molecule ligand
17 are solved with an approved drug

PTK7 is solved in complex with the approved drug(s):

COM/MESNA (4TT7_A),
STI/IMATINIB (3GVU_A, 4CSV_A),
1N1/DASATINIB (4XLI_A, 4XLI_B),
ADN/ADENOSINE (6FEK_A),
6GY/BRIGATINIB (6MX8_A),
VGH/CRIZOTINIB (2XP2_A, 2YFX_A, 3ZBF_A, 4ANQ_A, 4ANS_A, 5AAA_A, 5AAB_A, 5AAC_A),
EMH/ALECTINIB (3AOX_A),
0LI/PONATINIB (3IK3_A, 3IK3_B),
4MK/CERITINIB (4MKC_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PTK7 has been screened with compounds ( bioactivities). (see details)