MAPK7 (Q13164) - Overview - Molecular Target Synopsis
MAPK7, Mitogen-activated protein kinase 7
Enzyme Classification 126.96.36.199
Also Known as MK07_HUMAN, MAPK7, BMK1, ERK5, PRKM7
Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. Interacts with MAP2K5. Forms oligomers (By similarity). Interacts with MEF2A, MEF2C and MEF2D; the interaction phosphorylates the MEF2s and enhances transcriptional activity of MEF2A, MEF2C but not MEF2D (By similarity). Interacts with SGK1. Preferentially interacts with PML isoform PML-4 but shows interaction also with its other isoforms: isoform PML-1, isoform PML-2, isoform PML-3 and isoform PML-6. Interacts (via N-terminal half) with HSP90AB1-CDC37 chaperone complex in resting cells; the interaction is MAP2K5-independent and prevents MAPK7 from ubiquitination and proteasomal degradation (PubMed:23428871).
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|816||ENSG00000166484||ENST00000308406, ENST00000395604, ENST00000395602||ENSP00000311005, ENSP00000378968, ENSP00000378966||Q13164-1|
UniProt: MAPK7 is active in the following subcellular-locations: cytoplasm, nucleus, pml body.
GO terms: MAPK7 is active in the following subcellular-locations: cytoplasm, cytosol, nucleoplasm, nucleus, PML body.