Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PRDX4 (Q13162) - Overview - Molecular Target Synopsis

Protein


PRDX4, Peroxiredoxin-4
Enzyme Classification 1.11.1.15
UniProt Q13162

Also Known as PRDX4_HUMAN, PRDX4

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. Homodimer; disulfide-linked, upon oxidation (PubMed:9388242). 5 homodimers assemble to form a ring-like decamer (PubMed:21994946). Can form heterodimers with PRDX1 (PubMed:9388242).

5HQP
CRYSTAL STRUCTURE OF THE ERP44-PEROXIREDOXIN 4 COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for PRDX4

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PRDX4 is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum.
GO terms: PRDX4 is active in the following subcellular-locations: cytosol, endoplasmic reticulum, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, nucleus, secretory granule lumen, smooth endoplasmic reticulum.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PRDX4 has gain in 1 cell-lines, loss in 48 cell-lines and no signal in 956 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RPMI_8226, SNB_75, HOP_92

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-182, MOLP-2, SUM 52PE

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, A549, AG445

(see details)

3D Structures


For PRDX4 there are:
12 structures (67 chains) solved
1 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

PRDX4 is solved in complex with the approved drug(s):

COM/MESNA (4RQX_A, 4RQX_B, 4RQX_C, 4RQX_D, 4RQX_E).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PRDX4 has been screened with compounds ( bioactivities). (see details)