Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PPFIA1 (Q13136) - Overview - Molecular Target Synopsis

Protein


PPFIA1, Liprin-alpha-1
UniProt Q13136

Also Known as LIPA1_HUMAN, PPFIA1, LIP1

May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS. Interacts with GIT1, KIF1A and GRIP1.

1N7F
8 RESIDUE FRAGMENT OF
8-MER PEPTIDE FROM INTERACTING PROTEIN (LIPRIN)
IN THE STRUCTURE OF
CRYSTAL STRUCTURE OF THE SIXTH PDZ DOMAIN OF GRIP1 IN COMPLEX WITH LIPRIN C-TERMINAL PEPTIDE
RCSB/PDB
Inspect Structure
See all 3D Structures for PPFIA1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PPFIA1 is active in the following subcellular-locations: cytoplasm.
GO terms: PPFIA1 is active in the following subcellular-locations: cytoplasm, cytosol, focal adhesion, presynaptic active zone.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PPFIA1 has gain in 43 cell-lines, loss in 0 cell-lines and no signal in 962 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_2, OVCAR_8, UACC_257

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: FaDu, KYSE-510, MDA-MB-134-VI

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

3D Structures


For PPFIA1 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis