Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ZBTB17 (Q13105) - Overview - Molecular Target Synopsis

Protein


ZBTB17, Zinc finger and BTB domain-containing protein 17
UniProt Q13105

Also Known as ZBT17_HUMAN, ZBTB17, MIZ1, ZNF151, ZNF60

Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946). Homooligomerizes (via the BTB/POZ domain), multimerization is required for DNA binding. Interacts (via the C-terminal zinc fingers) with GIF1; the interaction results in the recruitment of MYB to the CDKN1A/p21 and CDKN1B promoters and repression of transcription. Interacts with TRAF2, interfering with the binding of UBC13 to TRAF2, and inhibiting TRAF2 E3 ligase activity. Interacts with MYC (via the C-terminal helix-loop-helix motif); the interaction inhibits ZBTB17 transactivation and growth arrest activities and renders it insoluble in the nucleus. Also interacts with HCFC1, MAGEA4 and TMPRSS11A. Interacts with BCL6; the interaction inhibits ZBTB17 transactivation activity on target genes involved in cell cycle arrest. Interacts with ZBTB49 isoform 3/ZNF509S1; this interaction blocks ZBTB17-mediated repression of RB1 (PubMed:25245946).

5ION
29 RESIDUE FRAGMENT OF
ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 17
IN THE STRUCTURE OF
SOLUTION STRUCTURE OF MIZ-1 ZINC FINGER 13
RCSB/PDB
Inspect Structure
See all 3D Structures for ZBTB17

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ZBTB17 is active in the following subcellular-locations: nucleus.
GO terms: ZBTB17 is active in the following subcellular-locations: nucleoplasm, protein-containing complex, protein-DNA complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ZBTB17 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, HOP_62, MOLT_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MKN-74, LN-18, SNU-398

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, HUVEC

(see details)

3D Structures


For ZBTB17 there are:
13 structures (21 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ZBTB17 has been screened with compounds ( bioactivities). (see details)