Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PLA2G7 (Q13093) - Overview - Molecular Target Synopsis

Protein


PLA2G7, Platelet-activating factor acetylhydrolase
Enzyme Classification 3.1.1.47
UniProt Q13093

Also Known as PAFA_HUMAN, PLA2G7, PAFAH

Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.

5YE9
THE CRYSTAL STRUCTURE OF LP-PLA2 IN COMPLEX WITH A NOVEL INHIBITOR
RCSB/PDB
Inspect Structure
See all 3D Structures for PLA2G7

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PLA2G7 is active in the following subcellular-locations: extracellular space, secreted.
GO terms: PLA2G7 is active in the following subcellular-locations: cytoplasm, extracellular region, low-density lipoprotein particle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PLA2G7 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HCT_116, MCF7, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 695T, PK-45P, NCI-H1734

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For PLA2G7 there are:
30 structures (43 chains) solved
29 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PLA2G7 has been screened with 515 compounds (1271 bioactivities), 317 compounds have bioactivities that show binding affinity of <= 500nM (385 bioactivities). (see details)