Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB40B (Q12829) - Overview - Molecular Target Synopsis

Protein


RAB40B, Ras-related protein Rab-40B
UniProt Q12829

Also Known as RB40B_HUMAN, RAB40B, SEC4L

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB40B is active in the following subcellular-locations: cell membrane.
GO terms: RAB40B is active in the following subcellular-locations: Golgi membrane, nuclear envelope, perinuclear region of cytoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB40B has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, HCC_2998, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H209, G124, GP2d

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, NHLF, BJ

(see details)

3D Structures


At greater than 35% identity similarity to RAB40B there are:
111 structures (239 chains) solved
100 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

RAB40B is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (3NKV_A, 3NKV_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB40B has been screened with compounds ( bioactivities). (see details)