Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RAB40B (Q12829) - Overview - Molecular Target Synopsis


RAB40B, Ras-related protein Rab-40B
UniProt Q12829

Also Known as RB40B_HUMAN, RAB40B, SEC4L

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: RAB40B is active in the following subcellular-locations: cell membrane.
GO terms: RAB40B is active in the following subcellular-locations: Golgi membrane, nuclear envelope, perinuclear region of cytoplasm, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RAB40B has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: MCF7, HCC_2998, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H209, G124, GP2d

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, NHLF, BJ

(see details)

3D Structures

At greater than 35% identity similarity to RAB40B there are:
111 structures (239 chains) solved
100 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

RAB40B is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

RAB40B has been screened with compounds ( bioactivities). (see details)