Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AIR2 (Q12476) - Overview - Molecular Target Synopsis

Protein


AIR2, Protein AIR2
UniProt Q12476

Also Known as AIR2_YEAST, AIR2

Component of the TRAMP (TRF4) complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met. Both complexes polyadenylate RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome. AIR2 also inhibits the methylation of NPL3 mediated by HMT1 through its interaction with HMT1. Component of the TRAMP complex (also called TRF4 complex) composed of at least HUL4, MTR4, PAP2/TRF4 and either AIR1 or AIR2. Interacts with HMT1 and NPL3. The interaction with NPL3 requires the presence of HMT1. Interacts directly with PAP2.

4U4C
THE MOLECULAR ARCHITECTURE OF THE TRAMP COMPLEX REVEALS THE ORGANIZATION AND INTERPLAY OF ITS TWO CATALYTIC ACTIVITIES
RCSB/PDB
Inspect Structure
See all 3D Structures for AIR2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
344Q12476-1

Sub-cellular localization


UniProt: AIR2 is active in the following subcellular-locations: nucleus.
GO terms: AIR2 is active in the following subcellular-locations: nucleolus, TRAMP complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AIR2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For AIR2 there are:
3 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis