Molecular Target Synopsis
Overview
Domains and Structures
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Ligand Efficiency Plot
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axe2 (Q09LX1) - Overview - Molecular Target Synopsis

Protein


axe2, Acetylxylan esterase
Enzyme Classification 3.1.1.72
UniProt Q09LX1

Also Known as AXE2_GEOSE, axe2

Acetylxylan esterase involved in the degradation of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Cleaves acetyl side groups from the xylose backbone units of the hemicellulolytic polymer xylan and xylo-oligosaccharides. Hydrolyzes about 20%-30% of the available acetyl groups on fully acetylated birch wood xylan. Completely deacetylates xylobiose peracetate (fully acetylated), and is active on both the alpha- and beta-forms of the sugar. Also hydrolyzes fully acetylated methyl-beta-D-xylopyranoside and methyl-beta-D-glucopyranoside, and the synthetic substrates 2-naphthyl acetate, 4-nitrophenyl acetate, 4-methylumbelliferyl acetate, and phenyl acetate. Homooctamer, presenting a unique donut-shaped quaternary structure built of two staggered tetrameric rings. The eight active sites are organized in four closely situated pairs, which face the relatively wide internal cavity.

5BN1
STRUCTURE OF AXE2-W215I, AN ACETYL XYLAN ESTERASE FROM GEOBACILLUS STEAROTHERMOPHILUS
RCSB/PDB
Inspect Structure
See all 3D Structures for axe2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
219Q09LX1-1

Sub-cellular localization


UniProt: axe2 is active in the following subcellular-locations: cytoplasm.
GO terms: axe2 is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project axe2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For axe2 there are:
8 structures (16 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis