Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

rad32 (Q09683) - Overview - Molecular Target Synopsis

Protein


rad32, DNA repair protein rad32
UniProt Q09683

Also Known as RAD32_SCHPO, rad32

Required for the repair of double strand breaks (DSB) caused by gamma and UV radiation. May work in conjunction with rhp51. Associates with nbn. Forms a multisubunit endonuclease complex, MRN, together with nbn and rad50.

4FBK
CRYSTAL STRUCTURE OF A COVALENTLY FUSED NBS1-MRE11 COMPLEX WITH ONE MANGANESE ION PER ACTIVE SITE
RCSB/PDB
Inspect Structure
See all 3D Structures for rad32

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
649Q09683-1

Sub-cellular localization


UniProt: rad32 is active in the following subcellular-locations: nucleus.
GO terms: rad32 is active in the following subcellular-locations: Mre11 complex, nuclear chromosome, site of double-strand break, subtelomeric heterochromatin.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project rad32 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For rad32 there are:
4 structures (8 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis