Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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ureH (Q09067) - Overview - Molecular Target Synopsis

Protein


ureH, Urease accessory protein UreH
UniProt Q09067

Also Known as UREH_HELPY, ureH

Required for maturation of urease via the functional incorporation of the urease nickel metallocenter. UreH, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

4HI0
CRYSTAL STRUCTURE OF HELICOBACTER PYLORI UREASE ACCESSORY PROTEIN UREF/H/G COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for ureH

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
265Q09067-1

Sub-cellular localization


UniProt: ureH is active in the following subcellular-locations: cytoplasm.
GO terms: ureH is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ureH has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For ureH there are:
2 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis