Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ureF (Q09065) - Overview - Molecular Target Synopsis

Protein


ureF, Urease accessory protein UreF
UniProt Q09065

Also Known as UREF_HELPY, ureF

Required for maturation of urease via the functional incorporation of the urease nickel metallocenter. UreH, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

4HI0
CRYSTAL STRUCTURE OF HELICOBACTER PYLORI UREASE ACCESSORY PROTEIN UREF/H/G COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for ureF

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
254Q09065-1

Sub-cellular localization


UniProt: ureF is active in the following subcellular-locations: cytoplasm.
GO terms: ureF is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ureF has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For ureF there are:
5 structures (13 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis